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    CSN1b COP9 signalosome subunit 1b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40063, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CSN1bprovided by FlyBase
    Official Full Name
    COP9 signalosome subunit 1bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027057
    Locus tag
    Dmel_CG3889
    See related
    AllianceGenome:FB:FBgn0027057
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3889; CH1-2; csn1; CSN1; csn1b; Csn1b; Csn1B; CSN1B; Dch1; Dch1-2; DCH1-2; dCSN1; Dmel\CG3889
    Summary
    Involved in several processes, including female germ-line stem cell population maintenance; germarium-derived cystoblast division; and male germ-line cyst encapsulation. Predicted to be part of COP9 signalosome. Is expressed in several structures, including ganglia and larval imaginal tissue. Orthologous to human GPS1 (G protein pathway suppressor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See CSN1b in Genome Data Viewer
    Location:
    75E4-75E4; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18903057..18904930, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18896157..18898030, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene asterix Neighboring gene uncharacterized protein Neighboring gene pre-mRNA processing factor 6 Neighboring gene Cytochrome c oxidase subunit 6A-like 2 Neighboring gene Ionotropic receptor 75d Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rbf1 degron dysfunction enhances cellular DNA replication. Raj N, et al. Cell Cycle, 2012 Oct 15. PMID 22895052, Free PMC Article
    2. Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression. Oron E, et al. Mol Syst Biol, 2007. PMID 17486136, Free PMC Article
    3. The COP9 signalosome is essential for development of Drosophila melanogaster. Freilich S, et al. Curr Biol, 1999 Oct 21. PMID 10531038
    4. Protein competition switches the function of COP9 from self-renewal to differentiation. Pan L, et al. Nature, 2014 Oct 9. PMID 25119050
    5. The COP9 signalosome. Wei N, et al. Annu Rev Cell Dev Biol, 2003. PMID 14570571

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived cystoblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male germ-line cyst encapsulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deneddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    COP9 signalosome subunit 1b
    Names
    CG3889-PA
    COP9 complex homolog subunit 1 b
    COP9 complex homolog subunit 1-2
    CSN1b-PA
    drosophila COP9 signalosome homolog 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18903057..18904930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079428.3 → NP_524152.2  COP9 signalosome subunit 1b [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524152.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVU5, Q9XYW3
      Related
      FBpp0074841
      Conserved Domains (2) summary
      pfam01399
      Location:353 → 457
      PCI; PCI domain
      pfam10602
      Location:159 → 338
      RPN7; 26S proteasome subunit RPN7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVU5.1 Q9VVU5

    Gene LinkOut

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