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    UQCR-C2 Ubiquinol-cytochrome c reductase core protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39846, updated on 17-Dec-2024

    Summary

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    Official Symbol
    UQCR-C2provided by FlyBase
    Official Full Name
    Ubiquinol-cytochrome c reductase core protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0250814
    Locus tag
    Dmel_CG4169
    See related
    AllianceGenome:FB:FBgn0250814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey245; BEST:GH10978; CG 4169; CG4169; Dmel\CG4169; dUQCRC2; UCR2; UQCR-cp2; UQCRC2
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Part of respiratory chain complex III. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and visceral mesoderm derivative. Used to study chromosome 16p12.1 deletion syndrome. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See UQCR-C2 in Genome Data Viewer
    Location:
    73A10-73A10; 3-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16584124..16586111)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16577224..16579211)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Regulatory particle non-ATPase 12 Neighboring gene antisense RNA:CR45895 Neighboring gene Syntaxin 8 Neighboring gene uncharacterized protein Neighboring gene lethal (3) 73Ah Neighboring gene transformer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 5-Aminolevulinic acid bypasses mitochondrial complex I deficiency and corrects physiological dysfunctions in Drosophila. Nozawa N, et al. Hum Mol Genet, 2023 Aug 7. PMID 37364055, Free PMC Article
    2. Modelling of BCS1L-related human mitochondrial disease in Drosophila melanogaster. Brischigliaro M, et al. J Mol Med (Berl), 2021 Oct. PMID 34274978, Free PMC Article
    3. Parkin expression reverses mitochondrial dysfunction in fused in sarcoma-induced amyotrophic lateral sclerosis. Cha SJ, et al. Insect Mol Biol, 2020 Feb. PMID 31290213
    4. Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model. O'Hanlon ME, et al. Neurobiol Dis, 2022 Sep. PMID 35764292
    5. Term-tissue specific models for prediction of gene ontology biological processes using transcriptional profiles of aging in drosophila melanogaster. Zhang W, et al. BMC Bioinformatics, 2008 Feb 28. PMID 18307794, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquinol-cytochrome c reductase core protein 2
    Names
    BEST:GH10978
    CG4169-PA
    CG4169-PB
    UQCR-C2-PA
    UQCR-C2-PB
    Ubiquinol-cytochrome C reductase complex core protein 2
    Ubiquinol-cytochrome c oxidoreductase core protein 2
    ubiquinol-cytochrome c reductase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16584124..16586111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140648.2 → NP_648905.1  Ubiquinol-cytochrome c reductase core protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648905.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV75
      Related
      FBpp0075069
      Conserved Domains (3) summary
      COG0612
      Location:22 → 417
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
      pfam00675
      Location:41 → 185
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:190 → 364
      Peptidase_M16_C; Peptidase M16 inactive domain

    2. NM_001275026.1 → NP_001261955.1  Ubiquinol-cytochrome c reductase core protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261955.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV75
      Conserved Domains (3) summary
      COG0612
      Location:22 → 417
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
      pfam00675
      Location:41 → 185
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:190 → 364
      Peptidase_M16_C; Peptidase M16 inactive domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VV75 Q9VV75

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