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    CG8001 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38224, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8001provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035268
    Locus tag
    Dmel_CG8001
    See related
    AllianceGenome:FB:FBgn0035268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8001
    Summary
    Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Human ortholog(s) of this gene implicated in giant axonal neuropathy 2. Orthologous to human DCAF8 (DDB1 and CUL4 associated factor 8); DCAF8L1 (DDB1 and CUL4 associated factor 8 like 1); and DCAF8L2 (DDB1 and CUL4 associated factor 8 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8001 in Genome Data Viewer
    Location:
    62B1-62B1; 3-1.0 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1756159..1759208)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1756159..1759208)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Glycerol kinase 2 Neighboring gene uncharacterized protein Neighboring gene Chitinase 2 Neighboring gene Dynein heavy chain at 62B Neighboring gene antisense RNA:CR44351 Neighboring gene uncharacterized protein Neighboring gene DNA polymerase delta subunit 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article
    2. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
    3. Comparative interactome analysis of α-arrestin families in human and Drosophila. Lee KT, et al. Elife, 2024 Jan 25. PMID 38270169, Free PMC Article
    4. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
    5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8001-PA
    CG8001-PB
    CG8001-PC
    CG8001-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1756159..1759208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139400.2 → NP_647657.1  uncharacterized protein Dmel_CG8001, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647657.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W091
      Related
      FBpp0072657
      Conserved Domains (3) summary
      COG2319
      Location:317 → 653
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:331 → 367
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:318 → 635
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001169853.1 → NP_001163324.1  uncharacterized protein Dmel_CG8001, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163324.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX92
      Conserved Domains (3) summary
      COG2319
      Location:312 → 648
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:326 → 362
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:313 → 630
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001274354.1 → NP_001261283.1  uncharacterized protein Dmel_CG8001, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261283.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W091
      Conserved Domains (3) summary
      COG2319
      Location:317 → 653
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:331 → 367
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:318 → 635
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_001274355.1 → NP_001261284.1  uncharacterized protein Dmel_CG8001, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261284.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX92
      Conserved Domains (3) summary
      COG2319
      Location:312 → 648
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:326 → 362
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:313 → 630
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX92 Q8SX92
    Q9W091 Q9W091

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