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    Dyrk2 Dual-specificity tyrosine phosphorylation-regulated kinase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34831, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dyrk2provided by FlyBase
    Official Full Name
    Dual-specificity tyrosine phosphorylation-regulated kinase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0016930
    Locus tag
    Dmel_CG4551
    See related
    AllianceGenome:FB:FBgn0016930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS01523.3; CG4551; dDYRK2; Dm2; DmDyrk2; Dmel\CG4551; DYRK; DYRK2; smi35A
    Summary
    Enables ATP binding activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including olfactory behavior; positive regulation of Wnt signaling pathway; and sensory perception of smell. Located in cytosol. Is expressed in several structures, including adult brain; adult mushroom body; embryonic/larval midgut primordium; mesoderm; and visceral mesoderm derivative. Orthologous to human DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dyrk2 in Genome Data Viewer
    Location:
    35A1-35A2; 2-50 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14184478..14234126, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14184478..14234126, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44727 Neighboring gene long non-coding RNA:CR44728

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs. Lochhead PA, et al. Cell, 2005 Jun 17. PMID 15960979
    2. dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila. Lochhead PA, et al. Biochem J, 2003 Sep 1. PMID 12786602, Free PMC Article
    3. Deep evolutionary conservation of an intramolecular protein kinase activation mechanism. Han J, et al. PLoS One, 2012. PMID 22235329, Free PMC Article
    4. Characterization of a domain that transiently converts class 2 DYRKs into intramolecular tyrosine kinases. Kinstrie R, et al. Sci Signal, 2010 Mar 2. PMID 20197545
    5. dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX. Kinstrie R, et al. Biochem J, 2006 Aug 15. PMID 16671894, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DmDyrk2 is expressed in developing sensory systems and it is required for the development of the visual system.
      Title: Drosophila Dyrk2 plays a role in the development of the visual system.
    2. We demonstrate that autophosphorylation of the critical activation-loop tyrosine is intramolecular and mediated by the nascent kinase passing through a transitory intermediate form
      Title: Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs.
    3. This is the first instance of phosphorylation of SNR1 or any of its homologues and implicates the DYRK family of kinases with a role in chromatin remodelling.
      Title: dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX.
    4. DYRK2 is an 81 kDa dual-specificity kinase that autophosphorylates on tyrosine and serine-threonine residues, but appears to phosphorylate exogenous substrates only on serine-threonine residues.
      Title: dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Dual-specificity tyrosine phosphorylation-regulated kinase 2
    Names
    CG4551-PA
    CG4551-PB
    CG4551-PC
    CG4551-PD
    CG4551-PE
    CG4551-PF
    CG4551-PG
    Dyrk2-PA
    Dyrk2-PB
    Dyrk2-PC
    Dyrk2-PD
    Dyrk2-PE
    Dyrk2-PF
    Dyrk2-PG
    dual specificity tyrosine phosphorylation-regulated kinase
    smell impaired 35A
    NP_001033906.1
    NP_001033907.1
    NP_001260455.1
    NP_001260456.1
    NP_523564.1
    NP_995710.1
    NP_995711.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14184478..14234126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_205988.3 → NP_995710.1  Dual-specificity tyrosine phosphorylation-regulated kinase 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995710.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0P7, Q8T0L9, Q9V3D5
      Conserved Domains (2) summary
      smart00220
      Location:198 → 494
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14225
      Location:151 → 494
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

    2. NM_205989.3 → NP_995711.1  Dual-specificity tyrosine phosphorylation-regulated kinase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995711.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0P7, Q8T0L9, Q9V3D5
      Conserved Domains (2) summary
      smart00220
      Location:198 → 494
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14225
      Location:151 → 494
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

    3. NM_001038817.1 → NP_001033906.1  Dual-specificity tyrosine phosphorylation-regulated kinase 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033906.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0P7, Q8T0L9, Q9V3D5
      Conserved Domains (2) summary
      smart00220
      Location:198 → 494
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14225
      Location:151 → 494
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

    4. NM_001038818.1 → NP_001033907.1  Dual-specificity tyrosine phosphorylation-regulated kinase 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033907.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0P7, Q8T0L9, Q9V3D5
      Conserved Domains (2) summary
      smart00220
      Location:198 → 494
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14225
      Location:151 → 494
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

    5. NM_001273526.1 → NP_001260455.1  Dual-specificity tyrosine phosphorylation-regulated kinase 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260455.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDF9
      Conserved Domains (2) summary
      smart00220
      Location:198 → 494
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14225
      Location:151 → 494
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

    6. NM_078840.5 → NP_523564.1  Dual-specificity tyrosine phosphorylation-regulated kinase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523564.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0P7, Q8T0L9, Q9V3D5
      Related
      FBpp0088344
      Conserved Domains (2) summary
      smart00220
      Location:198 → 494
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14225
      Location:151 → 494
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

    7. NM_001273527.1 → NP_001260456.1  Dual-specificity tyrosine phosphorylation-regulated kinase 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260456.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I0B8L2
      Conserved Domains (2) summary
      smart00220
      Location:233 → 529
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14225
      Location:186 → 529
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    I0B8L2 I0B8L2
    M9PDF9 M9PDF9
    Q9V3D5.1 Q9V3D5

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