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    CG41520 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740294, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG41520provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0087011
    Locus tag
    Dmel_CG41520
    See related
    AllianceGenome:FB:FBgn0087011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17443; CG40067; CG40109; Dmel\CG41520
    Summary
    Predicted to enable transmembrane receptor protein tyrosine kinase activator activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in embryonic epipharynx; embryonic hypopharynx; embryonic ventral epidermis; and embryonic/larval posterior spiracle. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; brain ischemia; diabetic retinopathy; hereditary angioedema; and hereditary lymphedema. Orthologous to several human genes including ANGPT1 (angiopoietin 1) and ANGPT2 (angiopoietin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG41520 in Genome Data Viewer
    Location:
    41A1-41A1; 2-55 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (1649061..1778937)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Branched chain keto acid dehydrogenase E1 subunit beta Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46487

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NT_033778.4 Chromosome 2R Reference Release 6 plus ISO1 MT Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytogenetic and molecular characterization of heterochromatin gene models in Drosophila melanogaster. Rossi F, et al. Genetics, 2007 Feb. PMID 17110485, Free PMC Article
    2. Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila. Caizzi R, et al. PLoS Genet, 2016 Aug. PMID 27513559, Free PMC Article
    3. Genetic atlas of hygro-and thermosensory cells in the vinegar fly Drosophila melanogaster. Corthals K, et al. Sci Rep, 2023 Sep 14. PMID 37709909, Free PMC Article
    4. Flying toward a plastic-free world: Can Drosophila serve as a model organism to develop new strategies of plastic waste management? Pignataro E, et al. Sci Total Environ, 2024 Mar 1. PMID 38199375
    5. circRNA biogenesis competes with pre-mRNA splicing. Ashwal-Fluss R, et al. Mol Cell, 2014 Oct 2. PMID 25242144

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 1700321-1707315 mobile_element_type = transposon:297{}6495

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane receptor protein tyrosine kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG41520-PA
    CG41520-PB
    CG41520-PC
    CG41520-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      1649061..1778937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201534.1 → NP_001188463.1  uncharacterized protein Dmel_CG41520, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188463.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8Z4Z6
      Conserved Domains (1) summary
      cd00087
      Location:398 → 615
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    2. NM_001110550.2 → NP_001104020.1  uncharacterized protein Dmel_CG41520, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104020.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8QHX1
      Conserved Domains (1) summary
      cd00087
      Location:516 → 717
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    3. NM_001110549.2 → NP_001104019.1  uncharacterized protein Dmel_CG41520, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104019.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BIB8
      Conserved Domains (1) summary
      cd00087
      Location:516 → 733
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    4. NM_001201533.1 → NP_001188462.1  uncharacterized protein Dmel_CG41520, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188462.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8Z4Z5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8QHX1 A8QHX1
    E8Z4Z5 E8Z4Z5
    E8Z4Z6 E8Z4Z6
    Q5BIB8 Q5BIB8

    Gene LinkOut

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