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    UQCR-11 Ubiquinol-cytochrome c reductase 11 kDa subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740185, updated on 17-Dec-2024

    Summary

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    Official Symbol
    UQCR-11provided by FlyBase
    Official Full Name
    Ubiquinol-cytochrome c reductase 11 kDa subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260008
    Locus tag
    Dmel_CG41623
    See related
    AllianceGenome:FB:FBgn0260008
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG41623; Dmel\CG41623; Ucrh; UCRH
    Summary
    Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be part of respiratory chain complex III. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to human UQCRH (ubiquinol-cytochrome c reductase hinge protein) and UQCRHL (ubiquinol-cytochrome c reductase hinge protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See UQCR-11 in Genome Data Viewer
    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (25120709..25126171)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3LHet NW_001848857.1 (606165..611627)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) AGGG subunit Neighboring gene Mediator complex subunit 21 Neighboring gene SET domain containing 1 Neighboring gene pseudo Neighboring gene loss of visual transmission Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The FAcilitates Chromatin Transcription complex regulates the ratio of glycolysis to oxidative phosphorylation in neural stem cells. Lou Y, et al. J Mol Cell Biol, 2024 Sep 30. PMID 38719542, Free PMC Article
    2. The misregulation of mitochondria-associated genes caused by GAGA-factor lack promotes autophagic germ cell death in Drosophila testes. Dorogova NV, et al. Genetica, 2023 Dec. PMID 37819589
    3. Sexually Antagonistic Mitonuclear Coevolution in Duplicate Oxidative Phosphorylation Genes. Havird JC, et al. Integr Comp Biol, 2019 Oct 1. PMID 30942855
    4. Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity. Rahman M, et al. J Cell Biol, 2014 Jul 21. PMID 25023514, Free PMC Article
    5. Genetic and Molecular Analysis of Essential Genes in Centromeric Heterochromatin of the Left Arm of Chromosome 3 in Drosophila melanogaster. Syrzycka M, et al. G3 (Bethesda), 2019 May 7. PMID 30948422, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquinol-cytochrome c reductase 11 kDa subunit
    Names
    CG41623-PB
    CG41623-PC
    CG41623-PD
    CG41623-PE
    CG41623-PF
    UQCR-11-PB
    UQCR-11-PC
    UQCR-11-PD
    UQCR-11-PE
    UQCR-11-PF
    Ubiquinol-cytochrome C reductase complex 11 kDa protein
    Ubiquinol-cytochrome c oxidoreductase 11 kDa
    Ubiquinol-cytochrome c reductase 11 kDa protein
    ucrh

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      25120709..25126171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170382.1 → NP_001163853.1  Ubiquinol-cytochrome c reductase 11 kDa subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163853.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y535, D2NUK7
      Conserved Domains (1) summary
      pfam02320
      Location:22 → 84
      UCR_hinge; Ubiquinol-cytochrome C reductase hinge protein

    2. NM_001300710.1 → NP_001287639.1  Ubiquinol-cytochrome c reductase 11 kDa subunit, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287639.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7EET3

    3. NM_001276234.1 → NP_001263163.1  Ubiquinol-cytochrome c reductase 11 kDa subunit, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7EET3

    4. NM_001110937.3 → NP_001104407.2  Ubiquinol-cytochrome c reductase 11 kDa subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104407.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y535, D2NUK7
      Conserved Domains (1) summary
      pfam02320
      Location:22 → 84
      UCR_hinge; Ubiquinol-cytochrome C reductase hinge protein

    5. NM_001170381.2 → NP_001163852.1  Ubiquinol-cytochrome c reductase 11 kDa subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163852.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y535, D2NUK7
      Conserved Domains (1) summary
      pfam02320
      Location:22 → 84
      UCR_hinge; Ubiquinol-cytochrome C reductase hinge protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8Y535 A8Y535
    L7EET3 L7EET3

    Gene LinkOut

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