ND-24 NADH dehydrogenase (ubiquinone) 24 kDa subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ND-24provided by FlyBase
Official Full Name: NADH dehydrogenase (ubiquinone) 24 kDa subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0030853
Locus tag: Dmel_CG5703
See related: AllianceGenome:FB:FBgn0030853
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:LP01573; CG 5703; CG5703; Dmel\CG5703; dNDUFV2; dNDUFV2A; ND24; Ndufv2; NDUFV2; NUHM; Q9VX36
Summary: Predicted to enable oxidoreductase activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity and NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in Parkinson's disease and nuclear type mitochondrial complex I deficiency 7. Orthologous to human NDUFV2 (NADH:ubiquinone oxidoreductase core subunit V2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (17632089..17633509)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (17526122..17527542)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to NADH dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IC Inferred by Curator more info	PubMed
involved_in mitochondrial electron transport, NADH to ubiquinone	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IC Inferred by Curator more info	PubMed
located_in mitochondrion	HDA more info	PubMed
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info

Names: CG5703-PA; CG5703-PB; COMPLEX I: 24 kDa subunit; NADH dehydrogenase ubiquinone flavoprotein 2; NADH ubiquinone oxidoreductase 24 kDa; NADH-ubiquinone oxidoreductase 24 kDa subunit; NADH:ubiquinone oxidoreductase 24 kDa subunit; ND-24-PA; ND-24-PB

NP_001285378.1

NP_573228.1

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The following sections contain reference sequences that belong to a specific genome build. Explain