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    Secp43 tRNA Selenocysteine associated protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Secp43provided by FlyBase
    Official Full Name
    tRNA Selenocysteine associated proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031607
    Locus tag
    Dmel_CG15440
    See related
    AllianceGenome:FB:FBgn0031607
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg15440; CG15440; Dmel\CG15440
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site recognition. Predicted to be active in cytosol. Orthologous to human TRNAU1AP (tRNA selenocysteine 1 associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Secp43 in Genome Data Viewer
    Location:
    24F3-24F3; 2-12 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4453169..4454453, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4453169..4454453, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Elongator complex protein 3 Neighboring gene Major Facilitator Superfamily Transporter 18 Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B8 subunit Neighboring gene ncRNA Neighboring gene GS1-like Neighboring gene Ribosomal protein L27A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Relaxation of selective constraints causes independent selenoprotein extinction in insect genomes. Chapple CE, et al. PLoS One, 2008 Aug 13. PMID 18698431, Free PMC Article
    2. mTORC1-chaperonin CCT signaling regulates m(6)A RNA methylation to suppress autophagy. Tang HW, et al. Proc Natl Acad Sci U S A, 2021 Mar 9. PMID 33649236, Free PMC Article
    3. spenito is required for sex determination in Drosophila melanogaster. Yan D, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26324914, Free PMC Article
    4. The drosophila melanogaster genome: translation factors and RNA binding proteins. Lasko P. J Cell Biol, 2000 Jul 24. PMID 10908586, Free PMC Article
    5. Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: a key component of neuronal homeostasis. Lin WH, et al. Dis Model Mech, 2017 Feb 1. PMID 28067623, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA selenocysteine associated protein
    Names
    CG15440-PA
    Secp43-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4453169..4454453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134993.2 → NP_608837.2  tRNA selenocysteine associated protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608837.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXG7, Q9VQZ9
      Related
      FBpp0077144
      Conserved Domains (2) summary
      cd12610
      Location:7 → 90
      RRM1_SECp43; RNA recognition motif 1 in tRNA selenocysteine-associated protein 1 (SECp43)
      cd12612
      Location:99 → 180
      RRM2_SECp43; RNA recognition motif 2 in tRNA selenocysteine-associated protein 1 (SECp43)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXG7 Q8SXG7

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