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    IntS2 Integrator 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32745, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IntS2provided by FlyBase
    Official Full Name
    Integrator 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0030858
    Locus tag
    Dmel_CG8211
    See related
    AllianceGenome:FB:FBgn0030858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8211; Dmel\CG8211; Int2; intS2
    Summary
    Involved in positive regulation of gene expression; positive regulation of neuron differentiation; and snRNA 3'-end processing. Predicted to be located in cytoplasm and nucleus. Predicted to be part of integrator complex. Orthologous to human INTS2 (integrator complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See IntS2 in Genome Data Viewer
    Location:
    16B10-16B10; 1-57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17652761..17656818, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17546794..17550851, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein p190 Neighboring gene uncharacterized protein Neighboring gene beta Spectrin Neighboring gene uncharacterized protein Neighboring gene chascon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Integrator Complex Prevents Dedifferentiation of Intermediate Neural Progenitors back into Neural Stem Cells. Zhang Y, et al. Cell Rep, 2019 Apr 23. PMID 31018143
    2. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article
    3. Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent. Jemc J, et al. Dev Biol, 2007 Oct 15. PMID 17714699, Free PMC Article
    4. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332
    5. Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module. Albrecht TR, et al. Nucleic Acids Res, 2018 May 4. PMID 29471365, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integrator 2
    Names
    CG8211-PA
    IntS2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17652761..17656818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133004.2 → NP_573232.1  integrator 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573232.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VX31
      Related
      FBpp0074254
      Conserved Domains (1) summary
      pfam14750
      Location:21 → 1054
      INTS2; Integrator complex subunit 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VX31.2 Q9VX31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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