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    cdi center divider [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42289, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdiprovided by FlyBase
    Official Full Name
    center dividerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004876
    Locus tag
    Dmel_CG6027
    See related
    AllianceGenome:FB:FBgn0004876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    91F; B9.3; Cdi; cdi/TESK1; Cdi/TESK1; CDI/TSKI; CG6027; Dmel\CG6027; l(3)07013
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in actin filament organization and negative regulation of sevenless signaling pathway. Located in apical part of cell and cytosol. Is expressed in several structures, including embryonic/larval epidermis; eye photoreceptor cell; eye-antennal disc; gut section; and male germline cell. Orthologous to human TESK1 (testis associated actin remodelling kinase 1) and TESK2 (testis associated actin remodelling kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cdi in Genome Data Viewer
    Location:
    91E4-91F1; 3-65 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19044882..19094270, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14870604..14919992, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46041 Neighboring gene ATP synthase, subunit D Neighboring gene mitochondrial ribosomal protein L55

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial ribosome-specific MrpL55 protein is essential in Drosophila and dynamically required during development. Tselykh TV, et al. Exp Cell Res, 2005 Jul 15. PMID 15894314
    2. The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development. Nambu JR, et al. Cell, 1991 Dec 20. PMID 1760843
    3. Drosophila single-minded gene and the molecular genetics of CNS midline development. Crews S, et al. J Exp Zool, 1992 Mar 1. PMID 1629656
    4. Single-minded regulation of genes in the embryonic midline of the Drosophila central nervous system. Muralidhar MG, et al. Mech Dev, 1993 May. PMID 8518191
    5. Translation of CircRNAs. Pamudurti NR, et al. Mol Cell, 2017 Apr 6. PMID 28344080, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A screen for modifiers of rotundracgap gain-of-function in the eye revealed cdi as a downstream effector of Rac1 during spermatogenesis.
      Title: A screen for modifiers of RacGAP(84C) gain-of-function in the Drosophila eye revealed the LIM kinase Cdi/TESK1 as a downstream effector of Rac1 during spermatogenesis.
    2. Data show interference with the function of the ADF/cofilin phosphatase Slingshot (ssh), which antagonizes Cdi, also results in a suppression of signaling triggered by the Sevenless RTK.
      Title: The Cdi/TESK1 kinase is required for Sevenless signaling and epithelial organization in the Drosophila eye.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of sevenless signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    center divider
    Names
    91F gene
    CG6027-PA
    CG6027-PB
    cdi-PA
    cdi-PB
    central divider
    centre divider
    centrer divider
    NP_001247191.1
    NP_524401.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19044882..19094270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260262.2 → NP_001247191.1  center divider, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247191.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K689
      Conserved Domains (2) summary
      smart00219
      Location:113 → 362
      TyrKc; Tyrosine kinase, catalytic domain
      cl21453
      Location:116 → 369
      PKc_like; Protein Kinases, catalytic domain

    2. NM_079677.4 → NP_524401.2  center divider, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524401.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VE06, Q9Y1A8
      Related
      FBpp0083130
      Conserved Domains (2) summary
      smart00219
      Location:113 → 363
      TyrKc; Tyrosine kinase, catalytic domain
      cl21453
      Location:116 → 370
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K689 A0A0B4K689
    Q95S32 Q95S32
    Q9VE06 Q9VE06
    Q9Y1A8 Q9Y1A8

    Gene LinkOut

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