U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG30491 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35704, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG30491provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050491
    Locus tag
    Dmel_CG30491
    See related
    AllianceGenome:FB:FBgn0050491
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17986; CG2074; Dmel\CG30491
    Summary
    Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinal metabolic process. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval salivary gland; and salivary gland body primordium. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 13 and Leber hereditary optic neuropathy. Orthologous to several human genes including RDH13 (retinol dehydrogenase 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG30491 in Genome Data Viewer
    Location:
    43E7-43E7; 2-57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7655072..7656770)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3542577..3544275)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Myosin-7a binding protein Neighboring gene antisense RNA:CR45131 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 1 Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor-like 43a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster. Belyaeva OV, et al. Biochim Biophys Acta, 2009 Oct. PMID 19520149, Free PMC Article
    2. Chromosomal instability causes sensitivity to metabolic stress. Shaukat Z, et al. Oncogene, 2015 Jul 30. PMID 25347746
    3. In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary. Nguyen TTM, et al. Development, 2023 Feb 15. PMID 36762624
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables all-trans-retinol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in retinal metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG30491-PA
    CG30491-PB
    NP_001260784.1
    NP_610306.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7655072..7656770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136462.2 → NP_610306.1  uncharacterized protein Dmel_CG30491, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610306.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JUS1
      Related
      FBpp0087993
      Conserved Domains (2) summary
      PRK06197
      Location:43 → 323
      PRK06197; short chain dehydrogenase; Provisional
      cl21454
      Location:45 → 319
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001273855.1 → NP_001260784.1  uncharacterized protein Dmel_CG30491, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JUS1
      Conserved Domains (2) summary
      PRK06197
      Location:43 → 323
      PRK06197; short chain dehydrogenase; Provisional
      cl21454
      Location:45 → 319
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JUS1 Q7JUS1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous