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    Cdc37 Cell division cycle 37 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc37provided by FlyBase
    Official Full Name
    Cell division cycle 37provided by FlyBase
    Primary source
    FLYBASE:FBgn0011573
    Locus tag
    Dmel_CG12019
    See related
    AllianceGenome:FB:FBgn0011573
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdc37; CG12019; CPDR-1; CPDR-2; Dmel\CG12019; DROCPDR; E(sev)3B
    Summary
    Enables insulin receptor binding activity. Involved in positive regulation of insulin receptor signaling pathway and positive regulation of neuroblast proliferation. Predicted to be active in cytoplasm. Is expressed in adult head; eye-antennal disc; and organism. Orthologous to several human genes including CDC37 (cell division cycle 37, HSP90 cochaperone). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cdc37 in Genome Data Viewer
    Location:
    62B4-62B4; 3-1.0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1795392..1797307)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1795392..1797307)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene alpha Spectrin Neighboring gene antisense RNA:CR45834 Neighboring gene discs lost Neighboring gene antisense RNA:CR45818 Neighboring gene uncharacterized protein Neighboring gene patj Neighboring gene uncharacterized protein Neighboring gene JTBR Neighboring gene antisense RNA:CR45686

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes. Lange BM, et al. EMBO J, 2002 Oct 15. PMID 12374737, Free PMC Article
    2. Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila. Cutforth T, et al. Cell, 1994 Jul 1. PMID 8020093
    3. Cdc37 is a molecular chaperone with specific functions in signal transduction. Kimura Y, et al. Genes Dev, 1997 Jul 15. PMID 9242486
    4. DPATJ plays a role in retinal morphogenesis and protects against light-dependent degeneration of photoreceptor cells in the Drosophila eye. Richard M, et al. Dev Dyn, 2006 Apr. PMID 16245332
    5. Hsp90 Mediates Membrane Deformation and Exosome Release. Lauwers E, et al. Mol Cell, 2018 Sep 6. PMID 30193096

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate a role of cochaperone-encoding gene cdc37 (Cdc37) in maintaining the stability of the JNK pathway kinases, thus mediating cell growth and migration during wound healing.
      Title: cdc37 is essential for JNK pathway activation and wound closure in Drosophila.
    2. loss of function leads to defects in mitosis and male meiosis
      Title: Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade HGI PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division cycle 37
    Names
    CG12019-PA
    Cdc37-PA
    cdc37 protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1795392..1797307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057658.5 → NP_477006.1  cell division cycle 37 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477006.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24276
      UniProtKB/TrEMBL
      C4IY07, Q86NM8
      Related
      FBpp0072660
      Conserved Domains (3) summary
      smart01071
      Location:1 → 121
      CDC37_N; Cdc37 N terminal kinase binding
      smart01069
      Location:283 → 372
      CDC37_C; Cdc37 C terminal domain
      smart01070
      Location:130 → 266
      CDC37_M; Cdc37 Hsp90 binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24276.1 Q24276
    Q86NM8 Q86NM8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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