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    Gprk1 G protein-coupled receptor kinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355013, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gprk1provided by FlyBase
    Official Full Name
    G protein-coupled receptor kinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0260798
    Locus tag
    Dmel_CG40129
    See related
    AllianceGenome:FB:FBgn0260798
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG40129; CT4320; Dmel\CG40129; Gprk-1; gprk1; GPRK1; RK; Rok
    Summary
    Enables several functions, including ATP binding activity; phosphatidylinositol binding activity; and rhodopsin kinase activity. Involved in negative regulation of phospholipase C-activating phototransduction signaling pathway; phototransduction, visible light; and positive regulation of smoothened signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Is expressed in adult head; head; organism; retina; and wing disc. Orthologous to human GRK2 (G protein-coupled receptor kinase 2) and GRK3 (G protein-coupled receptor kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gprk1 in Genome Data Viewer
    Location:
    41A1-41A1; 2-55 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4322295..4471060, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (209800..358565, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribonuclease kappa Neighboring gene Integrator 3 Neighboring gene long non-coding RNA:CR44100 Neighboring gene Ribosomal protein L38

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Chen Y, et al. Genes Dev, 2010 Sep 15. PMID 20844016, Free PMC Article
    2. Modeling Drosophila positional preferences in open field arenas with directional persistence and wall attraction. Soibam B, et al. PLoS One, 2012. PMID 23071591, Free PMC Article
    3. Isolation of Drosophila genes encoding G protein-coupled receptor kinases. Cassill JA, et al. Proc Natl Acad Sci U S A, 1991 Dec 15. PMID 1662381, Free PMC Article
    4. Regulation of PDF receptor signaling controlling daily locomotor rhythms in Drosophila. Li W, et al. PLoS Genet, 2022 May. PMID 35605015, Free PMC Article
    5. The history of the prolonged depolarizing afterpotential (PDA) and its role in genetic dissection of Drosophila phototransduction. Minke B. J Neurogenet, 2012 Jun. PMID 22428622

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c4374465-4369617 mobile_element_type = transposon:diver2{}6510

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables G protein-coupled receptor kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rhodopsin kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of phospholipase C-activating phototransduction signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction, visible light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    G protein-coupled receptor kinase 1
    Names
    CG40129-PA
    CG40129-PB
    CG40129-PC
    Gprk1-PA
    Gprk1-PB
    Gprk1-PC
    rhodopsin kinase
    NP_001036438.1
    NP_001163051.1
    NP_001286135.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      4322295..4471060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299206.1 → NP_001286135.1  G protein-coupled receptor kinase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286135.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJK1, P32865, Q4V555, Q7PLS9
      UniProtKB/TrEMBL
      E1JGX2
      Conserved Domains (5) summary
      cd08747
      Location:30 → 186
      RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
      cd01240
      Location:552 → 675
      PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
      pfam00069
      Location:191 → 454
      Pkinase; Protein kinase domain
      pfam00169
      Location:559 → 657
      PH; PH domain
      cl21453
      Location:185 → 531
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001169580.2 → NP_001163051.1  G protein-coupled receptor kinase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163051.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJK1, P32865, Q4V555, Q7PLS9
      UniProtKB/TrEMBL
      E1JGX2
      Conserved Domains (5) summary
      cd08747
      Location:30 → 186
      RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
      cd01240
      Location:552 → 675
      PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
      pfam00069
      Location:191 → 454
      Pkinase; Protein kinase domain
      pfam00169
      Location:559 → 657
      PH; PH domain
      cl21453
      Location:185 → 531
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001042973.3 → NP_001036438.1  G protein-coupled receptor kinase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036438.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJK1, P32865, Q4V555, Q7PLS9
      UniProtKB/TrEMBL
      E1JGX2
      Conserved Domains (5) summary
      cd08747
      Location:30 → 186
      RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
      cd01240
      Location:552 → 675
      PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
      pfam00069
      Location:191 → 454
      Pkinase; Protein kinase domain
      pfam00169
      Location:559 → 657
      PH; PH domain
      cl21453
      Location:185 → 531
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JGX2 E1JGX2
    P32865.2 P32865

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