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    mspo M-spondin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36632, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mspoprovided by FlyBase
    Official Full Name
    M-spondinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020269
    Locus tag
    Dmel_CG10145
    See related
    AllianceGenome:FB:FBgn0020269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10145; CT28539; Dmel\CG10145; m-spo; Mspo
    Summary
    Involved in regulation of myoblast fusion. Located in collagen-containing extracellular matrix. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval hypodermal muscle cell; ganglia; region of integument; and sensory nervous system primordium. Orthologous to human SPON2 (spondin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mspo in Genome Data Viewer
    Location:
    51B9-51C1; 2-72 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14671396..14713622, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10558901..10601127, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tarag Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene jet fuel

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. M-spondin, a novel ECM protein highly homologous to vertebrate F-spondin, is localized at the muscle attachment sites in the Drosophila embryo. Umemiya T, et al. Dev Biol, 1997 Jun 15. PMID 9205137
    2. Characterization and mutant analysis of the Drosophila sema 5c gene. Bahri SM, et al. Dev Dyn, 2001 Jul. PMID 11458392
    3. A green fluorescent protein enhancer trap screen in Drosophila photoreceptor cells. Mollereau B, et al. Mech Dev, 2000 May. PMID 10781948
    4. Dynamics of transcriptional (re)-programming of syncytial nuclei in developing muscles. Bataillé L, et al. BMC Biol, 2017 Jun 9. PMID 28599653, Free PMC Article
    5. Downstream of identity genes: muscle-type-specific regulation of the fusion process. Bataillé L, et al. Dev Cell, 2010 Aug 17. PMID 20708593, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    M-spondin
    Names
    CG10145-PA
    CG10145-PB
    m-spondin
    mspo-PA
    mspo-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14671396..14713622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299498.1 → NP_001286427.1  M-spondin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286427.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02029, Q7JY80
      Conserved Domains (2) summary
      smart00209
      Location:537 → 588
      TSP1; Thrombospondin type 1 repeats
      pfam06468
      Location:120 → 363
      Spond_N; Spondin_N

    2. NM_166063.2 → NP_725407.1  M-spondin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725407.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02029, Q7JY80
      Related
      FBpp0086606
      Conserved Domains (2) summary
      smart00209
      Location:537 → 588
      TSP1; Thrombospondin type 1 repeats
      pfam06468
      Location:120 → 363
      Spond_N; Spondin_N
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02029 O02029
    Q7JY80 Q7JY80

    Gene LinkOut

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