gskt gasket [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: gsktprovided by FlyBase
Official Full Name: gasketprovided by FlyBase
Primary source: FLYBASE:FBgn0046332
Locus tag: Dmel_CG31003
See related: AllianceGenome:FB:FBgn0046332
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:AT21229; BEST:GH16447; CG11338; CG31003; CT4237; Dm Gskt; Dmel\CG31003; GSK-3b; Gsk3b; GSK3b; Gskt; mjl; NEST:bs22e06; NGSK; SINA
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in male gamete generation. Predicted to be active in cytoplasm. Is expressed in adult head and male germline cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha) and GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31372427..31374198)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (27198149..27199920)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

A stop or go switch: glycogen synthase kinase 3beta phosphorylation of the kinesin 1 motor domain at Ser314 halts motility without detaching from microtubules.
Title: A stop or go switch: glycogen synthase kinase 3β phosphorylation of the kinesin 1 motor domain at Ser314 halts motility without detaching from microtubules.
Mojoless (mjl), a retroposed GSK-3, has functionally diverged to acquire an essential role in male fertility.
Title: Drosophila mojoless, a retroposed GSK-3, has functionally diverged to acquire an essential role in male fertility.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in male gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

NP_733426.1

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The following sections contain reference sequences that belong to a specific genome build. Explain