TfIIA-S Transcription-factor-IIA-S [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: TfIIA-Sprovided by FlyBase
Official Full Name: Transcription-factor-IIA-Sprovided by FlyBase
Primary source: FLYBASE:FBgn0013347
Locus tag: Dmel_CG5163
See related: AllianceGenome:FB:FBgn0013347
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE44302; CG5163; Dmel\CG5163; dTFIIA; dTFIIA-S; F121; TF-IIAS; TfIIA; TFIIA; tfiia-s; TFIIA-S
Summary: Enables TBP-class protein binding activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in heterochromatin and nucleus. Part of transcription factor TFIIA complex. Is expressed in several structures, including antennal primordium; anterior endoderm; embryonic/larval midgut primordium; gonad; and head epidermis primordium. Orthologous to human GTF2A2 (general transcription factor IIA subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23890388..23891060, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19716110..19716782, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to RNA polymerase II general transcription initiation factor activity	IPI Inferred from Physical Interaction more info	PubMed
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIA complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIA complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIA complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription factor TFIIA complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain