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    Ankrd49 Ankrd49 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ankrd49provided by FlyBase
    Official Full Name
    Ankrd49provided by FlyBase
    Primary source
    FLYBASE:FBgn0261881
    Locus tag
    Dmel_CG4140
    See related
    AllianceGenome:FB:FBgn0261881
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00929.2; br10; C3; CG4140; DAnkrd49; Dmel\CG4140; l(2)35Be; l(2)br10
    Summary
    Involved in regulation of establishment of planar polarity. Located in cytosol. Orthologous to human ANKRD49 (ankyrin repeat domain 49). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ankrd49 in Genome Data Viewer
    Location:
    35B8-35B8; 2-50 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15006583..15007431, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15006583..15007431, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45331 Neighboring gene moladietz Neighboring gene Dynactin 5, p25 subunit Neighboring gene Negative Cofactor 2beta Neighboring gene tRNA-histidine guanylyltransferase Neighboring gene RNA guanine-7 methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DAnkrd49 and Bdbt act via Casein kinase Iε to regulate planar polarity in Drosophila. Strutt H, et al. PLoS Genet, 2020 Aug. PMID 32750048, Free PMC Article
    2. The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. III. Hypomorphic and hypermorphic mutations affecting the expression of hairless. Ashburner M. Genetics, 1982 Jul-Aug. PMID 6816670, Free PMC Article
    3. Drosophila Morgana is an Hsp90-interacting protein with a direct role in microtubule polymerisation. Palumbo V, et al. J Cell Sci, 2020 Jan 23. PMID 31907206, Free PMC Article
    4. Genetic and cytogenetic analysis of the Adh region in Drosophila melanogaster. O'Donnell J, et al. Genetics, 1977 Jul. PMID 408228, Free PMC Article
    5. The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development. Furukawa T, et al. Cell, 1992 Jun 26. PMID 1617729

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of establishment of planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ankrd49
    Names
    Ankrd49-PA
    CG4140-PA
    lethal (2) 35Be
    lethal 10 in the black-reduced region
    lethal group C3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15006583..15007431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135891.4 → NP_609735.1  Ankrd49 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609735.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K028, Q9V3Y0
      Related
      FBpp0080287
      Conserved Domains (3) summary
      cd00204
      Location:54 → 169
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13857
      Location:67 → 120
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:52 → 79
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K028 Q7K028
    Q9V3Y0 Q9V3Y0
    Q9V3Y0.1

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