CadN Cadherin-N [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CadNprovided by FlyBase
Official Full Name: Cadherin-Nprovided by FlyBase
Primary source: FLYBASE:FBgn0015609
Locus tag: Dmel_CG7100
See related: AllianceGenome:FB:FBgn0015609
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:CL32; B; Cad-N; cad1; cadN; CG7100; CT21941; D-cad; Dmel\CG7100; DN; DN-cad; DN-Cad; DN-CAd; DN-CAD; DN-cadherin; DNcad; DNCad; l(2)36Da; l(2)Bld; n-cad; N-cad; N-Cad; N-Cadh; N-cadherin; N-Cadherin; ncad; Ncad; NCad; NCAD; S(DmcycE[JP])2.12
Summary: Enables cadherin binding activity; calcium ion binding activity; and protein homodimerization activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and neuron development. Located in several cellular components, including axon; cell-cell junction; and dendrite. Is expressed in several structures, including mushroom body; neuron projection bundle; organism subdivision; synaptic neuropil domain; and synaptic neuropil layer. Used to study prostate cancer. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 36D1-36D3; 2-53 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (17647053..17778340, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (17647053..17778340, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N-cadherin-dependent differential adhesion was identified within a columnar unit in the medulla oblongata.
Title: N-Cadherin Orchestrates Self-Organization of Neurons within a Columnar Unit in the Drosophila Medulla.
This is the first in vivo evidence for N-cadherin negatively and cell autonomously controlling collective migration.
Title: N-cadherin negatively regulates collective Drosophila glial migration through actin cytoskeleton remodeling.
Study demonstrates that the classical cadherin, N-cadherin, and an atypical cadherin, Flamingo, act redundantly to instruct the targeting choices made by every photoreceptor axon.
Title: A network of cadherin-mediated interactions polarizes growth cones to determine targeting specificity.
switching of CadN expression during neuronal differentiation involves regulated cation influx within neurons
Title: Developmental changes in expression, subcellular distribution, and function of Drosophila N-cadherin, guided by a cell-intrinsic program during neuronal differentiation.
Results suggest that N-cadherin is regulated in a Schizo/Loner- and d-Arf1-dependent manner.
Title: The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts.
These results suggest that, unlike their vertebrate counterparts, invertebrate cadherins may utilize multiple extracellular cadherin domains to form intercellular adhesive bonds.
Title: Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca²+-free interdomain linkers.
Data demonstrate that N-cadherin, DLAR, and Liprin-alpha function in a complex to regulate adhesive interactions between pre- and post-synaptic cells and provide a novel mechanism for controlling the activity of Liprin-alpha in the developing growth cone.
Title: Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting.
N-Cadherin gene maintained three sets of mutually-exclusive alternatively-spliced exons for over 400 million years.
Title: Conserved alternative splicing and expression patterns of arthropod N-cadherin.
N-cadherin expression on one growth cone in a specific layer is essential for targeting of processes of another neuron to this layer.
Title: Local N-cadherin interactions mediate distinct steps in the targeting of lamina neurons.
CadN alternative splicing might provide a novel mechanism to fine-tune its adhesive activity at different developmental stages or to restrict the use of high-affinity 18b-type isoforms at the adult stage.
Title: The variable transmembrane domain of Drosophila N-cadherin regulates adhesive activity.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in R7 cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R8 cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon target recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal fasciculation	TAS Traceable Author Statement more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IPI Inferred from Physical Interaction more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	IDA Inferred from Direct Assay more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Cadherin-N

Names: CG7100-PA; CG7100-PB; CG7100-PC; CG7100-PD; CG7100-PE; CG7100-PF; CG7100-PG; CG7100-PH; CG7100-PI; CG7100-PJ; CG7100-PK; CG7100-PL; CadN-PA; CadN-PB; CadN-PC; CadN-PD; CadN-PE; CadN-PF; CadN-PG; CadN-PH; CadN-PI; CadN-PJ; CadN-PK; CadN-PL; CadherinN; DN cadherin; DN-cadherin; DN-cadherin, N-cadherin; DN-cadherin1; drosophila neuronal cadherin; lethal(2)36Da; n-cadherin; nCadherin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

17647053..17778340 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165227.3 → NP_724071.1 Cadherin-N, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724071.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O15943, Q9VJB7

Related

FBpp0080568

Conserved Domains (7) summary

cd11304
Location:973 → 1074

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:1766 → 1859

CA; Cadherin repeats

cd00054
Location:2865 → 2903

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2381 → 2566

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:2346 → 2376

EGF; EGF-like domain

pfam01049
Location:2940 → 3086

Cadherin_C; Cadherin cytoplasmic region

cl29226
Location:449 → 541

Cadherin; Cadherin domain
NM_165231.3 → NP_724075.1 Cadherin-N, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724075.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O15943

Related

FBpp0080569

Conserved Domains (9) summary

cd11304
Location:973 → 1074

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:1215 → 1297

CA; Cadherin repeats

cd00054
Location:2865 → 2903

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2381 → 2566

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:2346 → 2376

EGF; EGF-like domain

pfam01049
Location:2948 → 3084

Cadherin_C; Cadherin cytoplasmic region

pfam02210
Location:2661 → 2796

Laminin_G_2; Laminin G domain

pfam07974
Location:2601 → 2627

EGF_2; EGF-like domain

cl09101
Location:449 → 541

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
NM_001032109.3 → NP_001027280.1 Cadherin-N, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027280.1

Status: REVIEWED

UniProtKB/TrEMBL

Q4ABF0

Conserved Domains (8) summary

cd11304
Location:973 → 1074

Cadherin_repeat; Cadherin tandem repeat domain

cd00054
Location:2868 → 2906

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2384 → 2569

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:2349 → 2379

EGF; EGF-like domain

pfam01049
Location:2951 → 3087

Cadherin_C; Cadherin cytoplasmic region

pfam02210
Location:2664 → 2799

Laminin_G_2; Laminin G domain

pfam07974
Location:2604 → 2630

EGF_2; EGF-like domain

cl09101
Location:449 → 541

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
NM_001032107.3 → NP_001027278.1 Cadherin-N, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027278.1

Status: REVIEWED

UniProtKB/TrEMBL

Q4ABE8

Conserved Domains (9) summary

cd11304
Location:973 → 1074

Cadherin_repeat; Cadherin tandem repeat domain

smart00179
Location:2826 → 2866

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:2869 → 2905

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2385 → 2570

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:2350 → 2380

EGF; EGF-like domain

pfam01049
Location:2951 → 3087

Cadherin_C; Cadherin cytoplasmic region

pfam02210
Location:2665 → 2800

Laminin_G_2; Laminin G domain

pfam07974
Location:2605 → 2631

EGF_2; EGF-like domain

cl09101
Location:449 → 541

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
NM_165224.2 → NP_724068.1 Cadherin-N, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724068.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O15943

Related

FBpp0080572

Conserved Domains (9) summary

cd11304
Location:973 → 1074

Cadherin_repeat; Cadherin tandem repeat domain

smart00179
Location:2821 → 2861

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:2864 → 2900

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2380 → 2565

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:2345 → 2375

EGF; EGF-like domain

pfam01049
Location:2946 → 3082

Cadherin_C; Cadherin cytoplasmic region

pfam02210
Location:2660 → 2795

Laminin_G_2; Laminin G domain

pfam07974
Location:2600 → 2626

EGF_2; EGF-like domain

cl09101
Location:449 → 541

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
NM_165225.2 → NP_724069.1 Cadherin-N, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724069.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O15943

Related

FBpp0080573

Conserved Domains (8) summary

cd11304
Location:973 → 1074

Cadherin_repeat; Cadherin tandem repeat domain

cd00054
Location:2864 → 2902

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2380 → 2565

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:2345 → 2375

EGF; EGF-like domain

pfam01049
Location:2947 → 3083

Cadherin_C; Cadherin cytoplasmic region

pfam02210
Location:2660 → 2795

Laminin_G_2; Laminin G domain

pfam07974
Location:2600 → 2626

EGF_2; EGF-like domain

cl09101
Location:449 → 541

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
NM_165226.2 → NP_724070.1 Cadherin-N, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724070.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O15943

Related

FBpp0080570

Conserved Domains (9) summary

cd11304
Location:973 → 1074

Cadherin_repeat; Cadherin tandem repeat domain

smart00179
Location:2822 → 2862

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:2865 → 2901

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2381 → 2566

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:2346 → 2376

EGF; EGF-like domain

pfam01049
Location:2947 → 3083

Cadherin_C; Cadherin cytoplasmic region

pfam02210
Location:2661 → 2796

Laminin_G_2; Laminin G domain

pfam07974
Location:2601 → 2627

EGF_2; EGF-like domain

cl09101
Location:449 → 541

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
NM_165228.2 → NP_724072.1 Cadherin-N, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724072.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O15943

Related

FBpp0080567

Conserved Domains (10) summary

cd11304
Location:973 → 1074

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:1215 → 1297

CA; Cadherin repeats

smart00179
Location:2821 → 2861

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:2864 → 2900

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2380 → 2565

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:2345 → 2375

EGF; EGF-like domain

pfam01049
Location:2946 → 3082

Cadherin_C; Cadherin cytoplasmic region

pfam02210
Location:2660 → 2795

Laminin_G_2; Laminin G domain

pfam07974
Location:2600 → 2626

EGF_2; EGF-like domain

cl09101
Location:449 → 541

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
NM_165229.2 → NP_724073.1 Cadherin-N, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724073.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O15943

Related

FBpp0080566

Conserved Domains (9) summary

cd11304
Location:973 → 1074

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:1215 → 1297

CA; Cadherin repeats

cd00054
Location:2864 → 2902

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2380 → 2565

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:2345 → 2375

EGF; EGF-like domain

pfam01049
Location:2947 → 3083

Cadherin_C; Cadherin cytoplasmic region

pfam02210
Location:2660 → 2795

Laminin_G_2; Laminin G domain

pfam07974
Location:2600 → 2626

EGF_2; EGF-like domain

cl09101
Location:449 → 541

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
NM_165230.2 → NP_724074.1 Cadherin-N, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724074.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O15943

Related

FBpp0080571

Conserved Domains (10) summary

cd11304
Location:973 → 1074

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:1215 → 1297

CA; Cadherin repeats

smart00179
Location:2822 → 2862

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:2865 → 2901

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2381 → 2566

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:2346 → 2376

EGF; EGF-like domain

pfam01049
Location:2947 → 3083

Cadherin_C; Cadherin cytoplasmic region

pfam02210
Location:2661 → 2796

Laminin_G_2; Laminin G domain

pfam07974
Location:2601 → 2627

EGF_2; EGF-like domain

cl09101
Location:449 → 541

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
NM_001032108.2 → NP_001027279.1 Cadherin-N, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027279.1

Status: REVIEWED

UniProtKB/TrEMBL

Q4ABE9

Conserved Domains (9) summary

cd11304
Location:973 → 1074

Cadherin_repeat; Cadherin tandem repeat domain

smart00179
Location:2825 → 2865

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:2868 → 2904

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2384 → 2569

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:2349 → 2379

EGF; EGF-like domain

pfam01049
Location:2950 → 3086

Cadherin_C; Cadherin cytoplasmic region

pfam02210
Location:2664 → 2799

Laminin_G_2; Laminin G domain

pfam07974
Location:2604 → 2630

EGF_2; EGF-like domain

cl09101
Location:449 → 541

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
NM_001032106.2 → NP_001027277.1 Cadherin-N, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027277.1

Status: REVIEWED

UniProtKB/TrEMBL

Q4ABE7

Conserved Domains (8) summary

cd11304
Location:973 → 1074

Cadherin_repeat; Cadherin tandem repeat domain

cd00054
Location:2869 → 2907

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2385 → 2570

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:2350 → 2380

EGF; EGF-like domain

pfam01049
Location:2952 → 3088

Cadherin_C; Cadherin cytoplasmic region

pfam02210
Location:2665 → 2800

Laminin_G_2; Laminin G domain

pfam07974
Location:2605 → 2631

EGF_2; EGF-like domain

cl09101
Location:449 → 541

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus