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    CG17646 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33354, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17646provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264494
    Locus tag
    Dmel_CG17646
    See related
    AllianceGenome:FB:FBgn0264494
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ABCG1; BEST:GH05015; CG17647; DmCG17646; Dmel\CG17646; l(2)SH0142; l(2)SH2 0142
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in triglyceride metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; brain; gut section; mushroom body extrinsic neurons; and mushroom body slice. Orthologous to human ABCG1 (ATP binding cassette subfamily G member 1) and ABCG4 (ATP binding cassette subfamily G member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17646 in Genome Data Viewer
    Location:
    22B1-22B2; 2-3 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1732524..1750612)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1732524..1750612)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Enolase Neighboring gene Ribosomal RNA processing 40 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduces adipose cell size and protects against diet-induced obesity. Buchmann J, et al. Endocrinology, 2007 Apr. PMID 17194745
    2. Dissecting neural pathways for forgetting in Drosophila olfactory aversive memory. Shuai Y, et al. Proc Natl Acad Sci U S A, 2015 Dec 1. PMID 26627257, Free PMC Article
    3. Mutants of the white ABCG Transporter in Drosophila melanogaster Have Deficient Olfactory Learning and Cholesterol Homeostasis. Myers JL, et al. Int J Mol Sci, 2021 Nov 30. PMID 34884779, Free PMC Article
    4. Opposing dopaminergic and GABAergic neurons control the duration and persistence of copulation in Drosophila. Crickmore MA, et al. Cell, 2013 Nov 7. PMID 24209625, Free PMC Article
    5. Three dopamine pathways induce aversive odor memories with different stability. Aso Y, et al. PLoS Genet, 2012. PMID 22807684, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    ATP-binding cassette transporter G1
    CG17646-PA
    CG17646-PB
    lethal (2) SH0142
    NP_608618.1
    NP_722727.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1732524..1750612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164436.2 → NP_722727.1  uncharacterized protein Dmel_CG17646, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722727.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9E6, Q9VQ41, Q9VQ42
      Related
      FBpp0077553
      Conserved Domains (3) summary
      cd03213
      Location:103 → 333
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:123 → 765
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:497 → 698
      ABC2_membrane; ABC-2 type transporter

    2. NM_134774.3 → NP_608618.1  uncharacterized protein Dmel_CG17646, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9E6, Q9VQ41, Q9VQ42
      Related
      FBpp0077554
      Conserved Domains (3) summary
      cd03213
      Location:103 → 333
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:123 → 765
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:497 → 698
      ABC2_membrane; ABC-2 type transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T9E6 Q8T9E6

    Gene LinkOut

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