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    Prosbeta5R2 Proteasome beta5 subunit-related 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318924, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prosbeta5R2provided by FlyBase
    Official Full Name
    Proteasome beta5 subunit-related 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0051742
    Locus tag
    Dmel_CG31742
    See related
    AllianceGenome:FB:FBgn0051742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    31742; anon-AE003657.1; beta5R2; CG31742; Dmel\CG31742
    Summary
    Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including PSMB5 (proteasome 20S subunit beta 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosbeta5R2 in Genome Data Viewer
    Location:
    36E3-36E3; 2-53 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17990418..17991951)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17990418..17991951)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene beethoven Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44767 Neighboring gene long non-coding RNA:CR44604

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome Profiling Following Neuronal and Glial Expression of ALS-Linked SOD1 in Drosophila. Kumimoto EL, et al. G3 (Bethesda), 2013 Apr 9. PMID 23550139, Free PMC Article
    2. Evidence for the fixation of gene duplications by positive selection in Drosophila. Cardoso-Moreira M, et al. Genome Res, 2016 Jun. PMID 27197209, Free PMC Article
    3. Duplicated proteasome subunit genes in Drosophila and their roles in spermatogenesis. Belote JM, et al. Heredity (Edinb), 2009 Jul. PMID 19277057
    4. Burst of young retrogenes and independent retrogene formation in mammals. Pan D, et al. PLoS One, 2009. PMID 19325906, Free PMC Article
    5. Age-dependent chromosomal distribution of male-biased genes in Drosophila. Zhang YE, et al. Genome Res, 2010 Nov. PMID 20798392, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome beta5 subunit-related 2
    Names
    AE003657 - proteasome beta subunit
    CG31742-PA
    CG31742-PB
    Prosbeta5R2-PA
    Prosbeta5R2-PB
    NP_001286022.1
    NP_724081.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17990418..17991951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299093.1 → NP_001286022.1  proteasome beta5 subunit-related 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286022.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INY4
      Conserved Domains (2) summary
      PTZ00488
      Location:46 → 279
      PTZ00488; Proteasome subunit beta type-5; Provisional
      cd03761
      Location:72 → 259
      proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    2. NM_165234.3 → NP_724081.1  proteasome beta5 subunit-related 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724081.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INY4
      Related
      FBpp0080578
      Conserved Domains (2) summary
      PTZ00488
      Location:46 → 279
      PTZ00488; Proteasome subunit beta type-5; Provisional
      cd03761
      Location:72 → 259
      proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8INY4 Q8INY4

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