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    Tpr2 Tetratricopeptide repeat protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34984, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Tpr2provided by FlyBase
    Official Full Name
    Tetratricopeptide repeat protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0032586
    Locus tag
    Dmel_CG4599
    See related
    AllianceGenome:FB:FBgn0032586
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD24941; CG4599; Dmel\CG4599; dtpr2; dTpr2; dTPR2; dtrpr2; EU3220; Tpr-2; tpr2; TPR2; Trp2
    Summary
    Predicted to enable heat shock protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol and nucleoplasm. Is expressed in adult head. Orthologous to human DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tpr2 in Genome Data Viewer
    Location:
    36A2-36A2; 2-52 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16491540..16507621)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16491540..16507621)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44994 Neighboring gene Neprilysin-like 8 Neighboring gene uncharacterized protein Neighboring gene mir-4943 stem loop Neighboring gene long non-coding RNA:CR45354

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic suppression of polyglutamine toxicity in Drosophila. Kazemi-Esfarjani P, et al. Science, 2000 Mar 10. PMID 10710314
    2. Beyond the Qs in the polyglutamine diseases. Orr HT. Genes Dev, 2001 Apr 15. PMID 11316786
    3. Identification of protein quality control regulators using a Drosophila model of TPI deficiency. Hrizo SL, et al. Neurobiol Dis, 2021 May. PMID 33600953, Free PMC Article
    4. AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease. Liévens JC, et al. Hum Mol Genet, 2008 Mar 15. PMID 18065778
    5. Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases. Ghosh S, et al. Hum Mol Genet, 2004 Sep 15. PMID 15254017

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heat shock protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 2
    Names
    CG4599-PA
    CG4599-PB
    CG4599-PC
    CG4599-PD
    CG4599-PE
    Tpr2-PA
    Tpr2-PB
    Tpr2-PC
    Tpr2-PD
    Tpr2-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16491540..16507621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273572.1 → NP_001260501.1  tetratricopeptide repeat protein 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGL2, Q9V3W1
      Conserved Domains (5) summary
      COG0484
      Location:401 → 503
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:310 → 344
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:402 → 469
      DnaJ; DnaJ domain
      pfam00515
      Location:231 → 264
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:49 → 114
      TPR_11; TPR repeat

    2. NM_001273573.1 → NP_001260502.1  tetratricopeptide repeat protein 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260502.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGL2, Q8IP18
      Conserved Domains (5) summary
      COG0484
      Location:357 → 459
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:266 → 300
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:358 → 425
      DnaJ; DnaJ domain
      pfam00515
      Location:187 → 220
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:5 → 70
      TPR_11; TPR repeat

    3. NM_078860.3 → NP_523584.1  tetratricopeptide repeat protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523584.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGL2, Q9V3W1
      Related
      FBpp0080423
      Conserved Domains (5) summary
      COG0484
      Location:401 → 503
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:310 → 344
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:402 → 469
      DnaJ; DnaJ domain
      pfam00515
      Location:231 → 264
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:49 → 114
      TPR_11; TPR repeat

    4. NM_165164.2 → NP_723974.1  tetratricopeptide repeat protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGL2, Q8IP18
      Related
      FBpp0080424
      Conserved Domains (5) summary
      COG0484
      Location:357 → 459
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:266 → 300
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:358 → 425
      DnaJ; DnaJ domain
      pfam00515
      Location:187 → 220
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:5 → 70
      TPR_11; TPR repeat

    5. NM_001273571.1 → NP_001260500.1  tetratricopeptide repeat protein 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260500.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDJ9, Q8IGL2
      Conserved Domains (5) summary
      COG0484
      Location:371 → 473
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:280 → 314
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:372 → 439
      DnaJ; DnaJ domain
      pfam00515
      Location:201 → 234
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:19 → 84
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDJ9 M9PDJ9
    Q8IGL2 Q8IGL2
    Q8IP18 Q8IP18
    Q9V3W1 Q9V3W1

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