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    dikar dikar [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dikarprovided by FlyBase
    Official Full Name
    dikarprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261934
    Locus tag
    Dmel_CG42799
    See related
    AllianceGenome:FB:FBgn0261934
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10115; CG32393; CG32394; CG42799; Dikar; Dmel\CG42799
    Old locus tag
    Dmel_CG32393; Dmel_CG32394
    Summary
    Involved in long-term memory. Predicted to be part of CERF complex and RSF complex. Is expressed in organism and spermatozoon. Orthologous to human CECR2 (CECR2 histone acetyl-lysine reader). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dikar in Genome Data Viewer
    Location:
    65C3-65C3; 3-17 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6728800..6743164, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6721900..6736264, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44523 Neighboring gene long non-coding RNA:CR45417 Neighboring gene veloren Neighboring gene SBDS ribosome maturation factor Neighboring gene Ist1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation analysis of Drosophila dikar/CG32394, homologue of the chromatin-remodelling gene CECR2. Keuling A, et al. Genome, 2007 Aug. PMID 17893736
    2. Generating customized transgene landing sites and multi-transgene arrays in Drosophila using phiC31 integrase. Knapp JM, et al. Genetics, 2015 Apr. PMID 25680812, Free PMC Article
    3. Muscle-derived Dpp regulates feeding initiation via endocrine modulation of brain dopamine biosynthesis. Robles-Murguia M, et al. Genes Dev, 2020 Jan 1. PMID 31831628, Free PMC Article
    4. The long-term memory trace formed in the Drosophila α/β mushroom body neurons is abolished in long-term memory mutants. Akalal DB, et al. J Neurosci, 2011 Apr 13. PMID 21490205, Free PMC Article
    5. An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development. Sotillos S, et al. Dev Biol, 2010 Apr 15. PMID 20171201, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CERF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RSF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RSF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    dikar
    Names
    CG42799-PB
    CG42799-PC
    CG42799-PD
    CG42799-PE
    CG42799-PF
    CG42799-PG
    dikar-PB
    dikar-PC
    dikar-PD
    dikar-PE
    dikar-PF
    dikar-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6728800..6743164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274552.1 → NP_001261481.1  dikar, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261481.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQ71
      Conserved Domains (2) summary
      cd05509
      Location:750 → 849
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam15612
      Location:100 → 148
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

    2. NM_001202125.2 → NP_001189054.1  dikar, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189054.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRW0
      Conserved Domains (2) summary
      cd05509
      Location:892 → 991
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam15612
      Location:100 → 148
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

    3. NM_168179.3 → NP_729188.2  dikar, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729188.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQ71
      Conserved Domains (2) summary
      cd05509
      Location:750 → 849
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam15612
      Location:100 → 148
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

    4. NM_001274551.1 → NP_001261480.1  dikar, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261480.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEI6
      Conserved Domains (2) summary
      cd05509
      Location:892 → 991
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam15612
      Location:100 → 148
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

    5. NM_139798.4 → NP_648055.1  dikar, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T11, Q9VRY3
      Related
      FBpp0292764
      Conserved Domains (1) summary
      pfam15612
      Location:100 → 148
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

    6. NM_206285.1 → NP_996007.1  dikar, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996007.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T11, Q9VRY3
      Conserved Domains (1) summary
      pfam15612
      Location:100 → 148
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRW0 M9MRW0
    M9PEI6 M9PEI6
    Q8IQ71 Q8IQ71
    Q95SM1 Q95SM1
    Q9VRY3 Q9VRY3

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