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    Ist1 Ist1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38750, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ist1provided by FlyBase
    Official Full Name
    Ist1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035715
    Locus tag
    Dmel_CG10103
    See related
    AllianceGenome:FB:FBgn0035715
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10103; Dist1; Dmel\CG10103
    Summary
    Predicted to be involved in endosome transport via multivesicular body sorting pathway and protein localization. Predicted to be located in endosome. Is expressed in adult head and organism. Orthologous to human IST1 (IST1 factor associated with ESCRT-III). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ist1 in Genome Data Viewer
    Location:
    65C3-65C4; 3-17 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6754017..6756497, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6747117..6749597, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene dikar Neighboring gene veloren Neighboring gene SBDS ribosome maturation factor Neighboring gene Radial spoke head protein 3 Neighboring gene long non-coding RNA:CR45759

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms. Bäumers M, et al. Biol Open, 2019 Sep 2. PMID 31412999, Free PMC Article
    2. Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation. Marie PP, et al. J Extracell Vesicles, 2023 Mar. PMID 36872252, Free PMC Article
    3. An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development. Sotillos S, et al. Dev Biol, 2010 Apr 15. PMID 20171201, Free PMC Article
    4. Signalling crosstalk at the leading edge controls tissue closure dynamics in the Drosophila embryo. Rousset R, et al. PLoS Genet, 2017 Feb. PMID 28231245, Free PMC Article
    5. Mitochondrial-Y chromosome epistasis in Drosophila melanogaster. Ågren JA, et al. Proc Biol Sci, 2020 Oct 28. PMID 33081607, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome transport via multivesicular body sorting pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Ist1
    Names
    CG10103-PA
    CG10103-PB
    CG10103-PC
    CG10103-PD
    CG10103-PE
    CG10103-PF
    Ist1-PA
    Ist1-PB
    Ist1-PC
    Ist1-PD
    Ist1-PE
    Ist1-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6754017..6756497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274556.1 → NP_001261485.1  Ist1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261485.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEJ2
      Conserved Domains (1) summary
      pfam03398
      Location:12 → 177
      Ist1; Regulator of Vps4 activity in the MVB pathway

    2. NM_001274554.1 → NP_001261483.1  Ist1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261483.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEC1
      Conserved Domains (1) summary
      pfam03398
      Location:12 → 177
      Ist1; Regulator of Vps4 activity in the MVB pathway

    3. NM_001274557.1 → NP_001261486.1  Ist1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261486.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHL4
      Conserved Domains (1) summary
      pfam03398
      Location:12 → 177
      Ist1; Regulator of Vps4 activity in the MVB pathway

    4. NM_001274555.1 → NP_001261484.1  Ist1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261484.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PES8
      Conserved Domains (1) summary
      pfam03398
      Location:12 → 177
      Ist1; Regulator of Vps4 activity in the MVB pathway

    5. NM_139801.3 → NP_648058.1  Ist1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648058.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRY6
      Related
      FBpp0076658
      Conserved Domains (1) summary
      pfam03398
      Location:12 → 177
      Ist1; Regulator of Vps4 activity in the MVB pathway

    6. NM_001274558.1 → NP_001261487.1  Ist1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBS9
      Conserved Domains (1) summary
      pfam03398
      Location:12 → 177
      Ist1; Regulator of Vps4 activity in the MVB pathway
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBS9 M9PBS9
    M9PEC1 M9PEC1
    M9PEJ2 M9PEJ2
    M9PES8 M9PES8
    M9PHL4 M9PHL4
    Q9VRY6 Q9VRY6

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