Med Medea [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Medprovided by FlyBase
Official Full Name: Medeaprovided by FlyBase
Primary source: FLYBASE:FBgn0288966
Locus tag: Dmel_CG1775
See related: AllianceGenome:FB:FBgn0288966
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3R16; anon-EST:Posey121; CG1775; demented; Dmel\CG1775; DMT; dSmad4; E(zen)3; l(3)11m-254; l(3)12m-137; l(3)SG36; l(3)SG70; l(3)XIIm137; med; MED; medea; smad4; Smad4; SMAD4
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; imaginal disc-derived appendage morphogenesis; and regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Part of RNA polymerase II transcription repressor complex and heteromeric SMAD protein complex. Is expressed in several structures, including follicle cell; ganglia; germ layer; gut section; and head epidermis primordium. Used to study intestinal cancer and juvenile polyposis syndrome. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 100C7-100D1; 3-102 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31611046..31615375)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (27436768..27441097)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Medea and schnurri mRNAs encode transcriptional regulators required for activation and/or repression of Dpp target genes.
Title: Coordinate post-transcriptional repression of Dpp-dependent transcription factors attenuates signal range during development.
Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient
Title: Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient.
we have compared genome occupancy of CBP with 40 different transcription factors in Drosophila embryos and find that master regulators of dorsal-ventral patterning, the transcription factors Dorsal and Medea, target CBP to the genome
Title: Preferential genome targeting of the CBP co-activator by Rel and Smad proteins in early Drosophila melanogaster embryos.
Reduction of the Medea or Smox, corrected both heart and muscle dysfunction in a Drosophila model of muscular dystrophy.
Title: SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy.
Medea SUMOylation provides a mechanism by which nuclei can continue to monitor the presence of extracellular Dpp signal to activate target gene expression for an appropriate duration
Title: Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo.
Data show that otefin is essential for germline stem cell (GSC) maintenance, is required for the Dpp/BMP signaling pathway to silence bam transcription, and that Ote physically interacts with Medea/Smad4 at the bam silencer element to regulate GSC fate.
Title: Otefin, a nuclear membrane protein, determines the fate of germline stem cells in Drosophila via interaction with Smad complexes.
The wider the separation, the more severely binding affinity was reduced by shortening of the linker region that tethers the DNA binding domain of Medea.
Title: Flexible interaction of Drosophila Smad complexes with bipartite binding sites.
the trimeric Mad-Medea complex binds Dpp-responsive silencers
Title: Dpp-responsive silencers are bound by a trimeric Mad-Medea complex.
compared patterns of two related cellular responses, both signal-dependent phosphorylation of the BMP-regulated R-SMAD, MAD, and signal-dependent changes in levels and sub-cellular distribution of the co-SMAD Medea
Title: Stepwise formation of a SMAD activity gradient during dorsal-ventral patterning of the Drosophila embryo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SMAD protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in activin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	TAS Traceable Author Statement more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of salivary gland boundary specification	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription repressor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of heteromeric SMAD protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heteromeric SMAD protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of heteromeric SMAD protein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: medea

Names: CG1775-PA; CG1775-PB; CG1775-PC; Med-PA; Med-PB; Med-PC; demented; lethal(3)SG36; lethal(3)SG70; media

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

31611046..31615375

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170560.2 → NP_733439.2 medea, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733439.2

Status: REVIEWED

UniProtKB/TrEMBL

O62609, O76259

Related

FBpp0307959

Conserved Domains (2) summary

cd10492
Location:42 → 166

MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4

cd10498
Location:543 → 760

MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4
NM_079871.4 → NP_524610.1 medea, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524610.1

Status: REVIEWED

UniProtKB/TrEMBL

O62609, O76259

Related

FBpp0085176

Conserved Domains (2) summary

cd10492
Location:42 → 166

MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4

cd10498
Location:543 → 760

MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4
NM_170559.3 → NP_733438.1 medea, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733438.1

Status: REVIEWED

UniProtKB/TrEMBL

O77069, Q8IMG6

Related

FBpp0085177

Conserved Domains (2) summary

cd10492
Location:42 → 166

MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4

cd10498
Location:469 → 686

MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4