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    Jwa Jwa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35128, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jwaprovided by FlyBase
    Official Full Name
    Jwaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032704
    Locus tag
    Dmel_CG10373
    See related
    AllianceGenome:FB:FBgn0032704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10373; djwa; Dmel\CG10373; GH05842p
    Summary
    Involved in response to ethanol. Located in endomembrane system. Is expressed in adult head and adult heart. Used to study alcohol use disorder. Orthologous to several human genes including PRAF2 (PRA1 domain family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jwa in Genome Data Viewer
    Location:
    37A1-37A1; 2-54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18704570..18705703, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18704570..18705703, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fas-associated factor 2 Neighboring gene Grip71 Neighboring gene Inwardly rectifying potassium channel 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila homolog of jwa is required for ethanol tolerance. Li C, et al. Alcohol Alcohol, 2008 Sep-Oct. PMID 18503079
    2. Flying Together: Drosophila as a Tool to Understand the Genetics of Human Alcoholism. Lathen DR, et al. Int J Mol Sci, 2020 Sep 11. PMID 32932795, Free PMC Article
    3. Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'. Engel GL, et al. Behav Brain Funct, 2019 Apr 16. PMID 30992041, Free PMC Article
    4. Identification of genetic loci that interact with cut during Drosophila wing-margin development. Krupp JJ, et al. Genetics, 2005 Aug. PMID 15956666, Free PMC Article
    5. Mediation of Drosophila autosomal dosage effects and compensation by network interactions. Malone JH, et al. Genome Biol, 2012 Apr 24. PMID 22531030, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Jwa
    Names
    CG10373-PC
    Jwa ortholog
    Jwa-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18704570..18705703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136057.2 → NP_609901.6  Jwa [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4LU22, Q8SXD0, Q9VJ59
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXD0 Q8SXD0
    Q9VJ59 Q9VJ59

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