RhoGAPp190 Rho GTPase activating protein p190 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: RhoGAPp190provided by FlyBase
Official Full Name: Rho GTPase activating protein p190provided by FlyBase
Primary source: FLYBASE:FBgn0026375
Locus tag: Dmel_CG32555
See related: AllianceGenome:FB:FBgn0026375
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 8267; BcDNA:GH17919; BcDNA:GM05133; CG32555; CG8240; CG8267; D-p190; Dmel\CG32555; DRhoGAP; mdcds_56566; p190; p190 RhoGAP; p190-RhoGAP; p190RhoGAP; RhoGAP; RhoGAP P190; RhoGAP-16B12; RhoGap190
Summary: Enables GTPase activator activity and semaphorin receptor binding activity. Involved in several processes, including Rho protein signal transduction; negative regulation of cell size; and nervous system development. Predicted to be active in cytosol. Is expressed in adult head; leg; and leg joint. Orthologous to human ARHGAP35 (Rho GTPase activating protein 35) and ARHGAP5 (Rho GTPase activating protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 16B10-16B10; 1-57 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (17639147..17652562, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (17533180..17546595, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonistrated that The Control of semaphorin-1a-mediated reverse signaling by opposing pebble and RhoGAPp190 functions in drosophila development.
Title: The Control of semaphorin-1a-mediated reverse signaling by opposing pebble and RhoGAPp190 functions in drosophila.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rho protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defasciculation of motor neuron axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell size	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Rho GTPase activating protein p190

Names: CG32555-PA; CG32555-PB; CG32555-PC; CG32555-PD; CG32555-PE; CG32555-PF; CG32555-PG; RhoGAPp190-PA; RhoGAPp190-PB; RhoGAPp190-PC; RhoGAPp190-PD; RhoGAPp190-PE; RhoGAPp190-PF; RhoGAPp190-PG; Rp190RhoGAP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

17639147..17652562 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272730.1 → NP_001259659.1 Rho GTPase activating protein p190, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259659.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PJQ3

Conserved Domains (3) summary

cd04373
Location:1188 → 1388

RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...

pfam16512
Location:254 → 333

RhoGAP-FF1; p190-A and -B Rho GAPs FF domain

cl21455
Location:148 → 238

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001272729.1 → NP_001259658.1 Rho GTPase activating protein p190, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259658.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHV3

Conserved Domains (3) summary

cd04373
Location:1411 → 1611

RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...

pfam16512
Location:254 → 333

RhoGAP-FF1; p190-A and -B Rho GAPs FF domain

cl21455
Location:148 → 238

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_167573.2 → NP_728090.1 Rho GTPase activating protein p190, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728090.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MRC6, Q95VZ5, Q9VX32

UniProtKB/TrEMBL

A0A0C5KMR0

Related

FBpp0074256

Conserved Domains (3) summary

cd04373
Location:1351 → 1551

RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...

pfam16512
Location:254 → 333

RhoGAP-FF1; p190-A and -B Rho GAPs FF domain

cl21455
Location:148 → 238

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001272728.1 → NP_001259657.1 Rho GTPase activating protein p190, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259657.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHY4

Conserved Domains (3) summary

cd04373
Location:1369 → 1569

RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...

pfam16512
Location:254 → 333

RhoGAP-FF1; p190-A and -B Rho GAPs FF domain

cl21455
Location:148 → 238

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001272727.1 → NP_001259656.1 Rho GTPase activating protein p190, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259656.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHG0

Conserved Domains (3) summary

cd04373
Location:1354 → 1554

RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...

pfam16512
Location:254 → 333

RhoGAP-FF1; p190-A and -B Rho GAPs FF domain

cl21455
Location:148 → 238

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_167572.2 → NP_728089.1 Rho GTPase activating protein p190, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728089.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MRC6, Q95VZ5, Q9VX32

UniProtKB/TrEMBL

A0A0C5KMR0

Related

FBpp0074257

Conserved Domains (3) summary

cd04373
Location:1351 → 1551

RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...

pfam16512
Location:254 → 333

RhoGAP-FF1; p190-A and -B Rho GAPs FF domain

cl21455
Location:148 → 238

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_133003.3 → NP_573231.2 Rho GTPase activating protein p190, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_573231.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MRC6, Q95VZ5, Q9VX32

UniProtKB/TrEMBL

A0A0C5KMR0

Related

FBpp0074255

Conserved Domains (3) summary

cd04373
Location:1351 → 1551

RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...

pfam16512
Location:254 → 333

RhoGAP-FF1; p190-A and -B Rho GAPs FF domain

cl21455
Location:148 → 238

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases