Cd8b1 CD8 subunit beta 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd8b1provided by MGI
Official Full Name: CD8 subunit beta 1provided by MGI
Primary source: MGI:MGI:88347
See related: Ensembl:ENSMUSG00000053044 AllianceGenome:MGI:88347
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd8b; Ly-3; Ly-C; Lyt-3
Summary: Predicted to enable MHC class I protein binding activity and coreceptor activity. Predicted to be involved in T cell activation and T cell receptor signaling pathway. Located in external side of plasma membrane. Part of receptor complex. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to several human genes including CD8B (CD8 subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward thymus adult (RPKM 247.7) See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 32.14 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (71299772..71314476)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (71322788..71337492)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ribosylation of the CD8alphabeta heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10.
Title: Ribosylation of the CD8αβ heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10.
Constitutive CD8 expression drives innate CD8(+) T-cell differentiation via induction of iNKT2 cells.
Title: Constitutive CD8 expression drives innate CD8(+) T-cell differentiation via induction of iNKT2 cells.
Lck-CD8 interaction is required for initial CD8 recruitment.
Title: Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.
Comparing the sequences of mouse, human, rat and dog Cd8a and Cd8b1 gene loci identified 10 evolutionarily conserved regions (ECR). 6 ECRs overlapped with previously identified Cd8 enhancers. ECR-4 recruits transcription factors to the Cd8ab gene complex.
Title: A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.
CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a.
Title: cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.
We propose that ADP-ribosylation of CD8-beta can regulate the coreceptor function of CD8 in the presence of elevated levels of extracellular NAD(+) .
Title: CD8-β ADP-ribosylation affects CD8(+) T-cell function.
Data indicate that CD8low cells survive long term in vivo.
Title: Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo.
The crystal structure of CD8alphabeta in complex with H-2Dd antigen indicates that CD8beta is crucial in orienting the CD8alphabeta heterodimer.
Title: Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position.
Results identify novel functions for both CD8 and LAT during CD8-mediated apoptosis that are independent of TCR signal transduction and suggest a mechanism for signal transduction leading to apoptosis upon CD8 crosslinking.
Title: A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction.
The stalk region of CD8beta influences the ability of CD8 to bind class I major histocompatibility complexes and is therefore critical for the correct functioning of CD8alphabeta heterodimers.
Title: An essential role for the stalk region of CD8 beta in the coreceptor function of CD8.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (3)
Not Applicable (1)
Targeted (2) 1 citation

General gene information

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Markers

D6Mit124 (e-PCR), detects polymorphism
- UniSTS:130665

D6Mit16 (e-PCR), detects polymorphism
- UniSTS:130703

Cd8b (e-PCR), detects polymorphism
- UniSTS:141299

Cd8b (e-PCR), detects polymorphism
- UniSTS:141300

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class I protein binding	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: T-cell surface glycoprotein CD8 beta chain

Names: CD8 antigen, beta chain 1; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein Lyt-3; lymphocyte antigen 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.