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    Sik3 Salt-inducible kinase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37152, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Sik3provided by FlyBase
    Official Full Name
    Salt-inducible kinase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0262103
    Locus tag
    Dmel_CG42856
    See related
    AllianceGenome:FB:FBgn0262103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15072; CG18604; CG42856; Dmel\CG42856; EMK/KIAA0999; SIK; SIK3
    Old locus tag
    Dmel_CG15072; Dmel_CG18604
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of hippo signaling; and regulation of catabolic process. Predicted to be active in cytoplasm and nucleus. Is expressed in organism. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sik3 in Genome Data Viewer
    Location:
    55E6-55E9; 2-86 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18688132..18705805)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14575637..14593310)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR33942 Neighboring gene Vacuolar protein sorting 51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A phosphorylation-deficient mutant of Sik3, a homolog of Sleepy, alters circadian sleep regulation by PDF neurons in Drosophila. Kobayashi R, et al. Front Neurosci, 2023. PMID 37662102, Free PMC Article
    2. SIK3-HDAC4 signaling regulates Drosophila circadian male sex drive rhythm via modulating the DN1 clock neurons. Fujii S, et al. Proc Natl Acad Sci U S A, 2017 Aug 8. PMID 28743754, Free PMC Article
    3. LKB1 is physiologically required for sleep from Drosophila melanogaster to the Mus musculus. Liu Z, et al. Genetics, 2022 Jul 4. PMID 35579349, Free PMC Article
    4. Forward-genetics analysis of sleep in randomly mutagenized mice. Funato H, et al. Nature, 2016 Nov 17. PMID 27806374, Free PMC Article
    5. Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells. Zhang C, et al. J Cell Sci, 2021 Sep 1. PMID 34350957, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SIK3 and Wnk converge on Fray to regulate glial K+ buffering and seizure susceptibility.
      Title: SIK3 and Wnk converge on Fray to regulate glial K+ buffering and seizure susceptibility.
    2. SIK3 promotes the cytosolic localization of HDAC4, thereby relieving inhibition of Mef2-dependent transcription of K(+) and water transport molecules
      Title: SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K(+) and water.
    3. Study identifies Salt-inducible kinase 3 (SIK3), a member of the AMP-activated protein kinase (AMPK)-related kinase family, as a key determinant of Drosophila sugar tolerance.
      Title: Salt-Inducible Kinase 3 Provides Sugar Tolerance by Regulating NADPH/NADP(+) Redox Balance.
    4. SIK3-HDAC4 signaling in M cells regulates MSDR by regulating the molecular oscillation in DN1 neurons.
      Title: SIK3-HDAC4 signaling regulates Drosophila circadian male sex drive rhythm via modulating the DN1 clock neurons.
    5. Drosophila salt-inducible kinases Sik2 and Sik3 are negative regulators of Hpo signalling.
      Title: Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of triglyceride catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of pentose-phosphate shunt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Salt-inducible kinase 3
    Names
    CG42856-PA
    CG42856-PB
    CG42856-PC
    CG42856-PD
    CG42856-PE
    CG42856-PF
    Sik3-PA
    Sik3-PB
    Sik3-PC
    Sik3-PD
    Sik3-PE
    Sik3-PF
    NP_001097369.2
    NP_001097370.2
    NP_001188969.1
    NP_001286587.1
    NP_611359.1
    NP_611361.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18688132..18705805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202040.1 → NP_001188969.1  Salt-inducible kinase 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188969.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBC4
      Conserved Domains (3) summary
      smart00220
      Location:41 → 292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14338
      Location:335 → 380
      UBA_SIK; UBA domain found in salt-inducible kinase SIK1, SIK2, SIK3 and similar proteins
      cl21453
      Location:40 → 292
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001299658.1 → NP_001286587.1  Salt-inducible kinase 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFW1
      Conserved Domains (3) summary
      smart00220
      Location:41 → 292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14338
      Location:335 → 380
      UBA_SIK; UBA domain found in salt-inducible kinase SIK1, SIK2, SIK3 and similar proteins
      cl21453
      Location:40 → 292
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001103900.2 → NP_001097370.2  Salt-inducible kinase 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097370.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYI5
      Conserved Domains (3) summary
      smart00220
      Location:41 → 292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14338
      Location:335 → 380
      UBA_SIK; UBA domain found in salt-inducible kinase SIK1, SIK2, SIK3 and similar proteins
      cl21453
      Location:40 → 292
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001103899.2 → NP_001097369.2  Salt-inducible kinase 3, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097369.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYI4
      Conserved Domains (3) summary
      smart00220
      Location:41 → 292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14338
      Location:335 → 380
      UBA_SIK; UBA domain found in salt-inducible kinase SIK1, SIK2, SIK3 and similar proteins
      cl21453
      Location:40 → 292
      PKc_like; Protein Kinases, catalytic domain

    5. NM_137517.5 → NP_611361.4  Salt-inducible kinase 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611361.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBC4
      Conserved Domains (3) summary
      smart00220
      Location:41 → 292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14338
      Location:335 → 380
      UBA_SIK; UBA domain found in salt-inducible kinase SIK1, SIK2, SIK3 and similar proteins
      cl21453
      Location:40 → 292
      PKc_like; Protein Kinases, catalytic domain

    6. NM_137515.3 → NP_611359.1  Salt-inducible kinase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611359.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QQA7
      Related
      FBpp0292993
      Conserved Domains (3) summary
      smart00220
      Location:41 → 292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14338
      Location:335 → 380
      UBA_SIK; UBA domain found in salt-inducible kinase SIK1, SIK2, SIK3 and similar proteins
      cl21453
      Location:40 → 292
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFW1 A0A0B4LFW1
    A1ZBC4 A1ZBC4
    A8DYI4 A8DYI4
    A8DYI5 A8DYI5
    Q4QQA7 Q4QQA7
    Q7K243 Q7K243

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