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    tow target of wingless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38755, updated on 9-Dec-2024

    Summary

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    Official Symbol
    towprovided by FlyBase
    Official Full Name
    target of winglessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035719
    Locus tag
    Dmel_CG14821
    See related
    AllianceGenome:FB:FBgn0035719
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14821; Dmel\CG14821; Tow
    Summary
    Involved in establishment of planar polarity; imaginal disc-derived wing hair organization; and negative regulation of smoothened signaling pathway. Located in nucleus. Is expressed in several structures, including adult head; ganglia; larval nervous system; and wing disc. Orthologous to human C1orf21 (chromosome 1 open reading frame 21). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tow in Genome Data Viewer
    Location:
    65D3-65D3; 3-18 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6942856..6949313)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6935956..6942413)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45414 Neighboring gene long non-coding RNA:CR45412 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase complex assembly factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates. Sela N, et al. Genome Biol, 2010. PMID 20525173, Free PMC Article
    2. Spatiotemporally modulated Vestigial gradient by Wingless signaling adaptively regulates cell division for precise wing size control. Zhu H. J Theor Biol, 2011 Jan 7. PMID 20932848
    3. Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila. Ayers KL, et al. Dev Biol, 2009 May 15. PMID 19285058
    4. The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing. Chung S, et al. Genetics, 2007 Jun. PMID 17409077, Free PMC Article
    5. An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development. Sotillos S, et al. Dev Biol, 2010 Apr 15. PMID 20171201, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studies indicate that negative regulation of the Vestigial gradient by Wingless signaling makes vestigial expression precise and robust.
      Title: Spatiotemporally modulated Vestigial gradient by Wingless signaling adaptively regulates cell division for precise wing size control.
    2. results demonstrate that Tow is an important novel regulator of the Hh pathway in the wing imaginal disc, and may shed light on the mechanism of Ptc repression of Smo
      Title: Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila.
    3. Target of Wingless (tow) acts downstream of Fz/Dsh and plays a role in restricting the number of hairs that wing cells form.
      Title: The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in establishment of planar polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing hair organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    target of wingless
    Names
    CG14821-PC
    CG14821-PD
    CG14821-PE
    CG14821-PF
    CG14821-PG
    tow-PC
    tow-PD
    tow-PE
    tow-PF
    tow-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6942856..6949313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274559.1 → NP_001261488.1  target of wingless, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261488.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNM0
      Conserved Domains (1) summary
      pfam15389
      Location:2 → 116
      DUF4612; Domain of unknown function (DUF4612)

    2. NM_001274561.1 → NP_001261490.1  target of wingless, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261490.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEJ7
      Conserved Domains (1) summary
      pfam15389
      Location:2 → 111
      DUF4612; Domain of unknown function (DUF4612)

    3. NM_001274560.1 → NP_001261489.1  target of wingless, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261489.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PET2
      Conserved Domains (1) summary
      pfam15389
      Location:2 → 116
      DUF4612; Domain of unknown function (DUF4612)

    4. NM_139804.2 → NP_648061.2  target of wingless, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648061.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRZ4
      Conserved Domains (1) summary
      pfam15389
      Location:2 → 111
      DUF4612; Domain of unknown function (DUF4612)

    5. NM_001104056.2 → NP_001097526.1  target of wingless, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097526.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNM0
      Conserved Domains (1) summary
      pfam15389
      Location:2 → 116
      DUF4612; Domain of unknown function (DUF4612)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNM0 A8JNM0
    M9PEJ7 M9PEJ7
    M9PET2 M9PET2
    Q7JWR6 Q7JWR6
    Q9VRZ4 Q9VRZ4

    Gene LinkOut

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