Fgr FGR proto-oncogene, Src family tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgrprovided by MGI
Official Full Name: FGR proto-oncogene, Src family tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:95527
See related: Ensembl:ENSMUSG00000028874 AllianceGenome:MGI:95527
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ali18; Mhdaali18
Summary: Enables several functions, including immunoglobulin receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including integrin-mediated signaling pathway; negative regulation of natural killer cell activation; and regulation of vesicle-mediated transport. Acts upstream of or within bone mineralization and skeletal system morphogenesis. Located in plasma membrane. Colocalizes with actin cytoskeleton and ruffle membrane. Is expressed in 2-cell stage embryo; blastocyst; metanephros; nervous system; and neural ectoderm. Orthologous to human FGR (FGR proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in spleen adult (RPKM 12.8), lung adult (RPKM 4.7) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.11 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (132701406..132729204)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (132974095..133001893)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fgr contributes to hemorrhage-induced thalamic pain by activating NF-kappaB/ERK1/2 pathways.
Title: Fgr contributes to hemorrhage-induced thalamic pain by activating NF-κB/ERK1/2 pathways.
Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity.
Title: Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity.
A loss of a single Src family kinase, Fgr or Lyn, reduced platelet-mediated monocyte recruitment in vitro and a significant reduction in the burden of atherosclerotic disease in Fgr(-/-) /ApoE(-/-) or Lyn(-/-) /ApoE(-/-) animals.
Title: Signalling through Src family kinase isoforms is not redundant in models of thrombo-inflammatory vascular disease.
the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is required for efficient uptake.
Title: The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.
Data indicate that Src-Family Kinases Hck and Fgr regulate cytokine secretion by macrophages.
Title: The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines.
Fgr is not only are progressively overexpressed in atherosclerosis, but it also controls critical molecular processes in monocyte influx, blood monocyte subset balance, macrophage accumulation, and the maintenance of atherosclerotic lesion stability.
Title: Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility.
Ablation of Fgr abolishes the capacity of mitochondria to adjust metabolism upon nutrient restriction, hypoxia/reoxygenation, and T cell activation, demonstrating the physiological relevance of this adaptive response.
Title: ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use.
The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
Title: The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.
Title: The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.
Despite possessing enhanced killing, alveolar macrophage Fgr/Hck/Lyn-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.
Title: IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Fc-gamma receptor I complex binding	IEA Inferred from Electronic Annotation more info
enables Fc-gamma receptor I complex binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables immunoglobulin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of natural killer cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mast cell degranulation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in aggresome	IEA Inferred from Electronic Annotation more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
colocalizes_with cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with ruffle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase Fgr

Names: Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog; p55-Fgr; proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase Fgr

NP_034338.3

EC 2.7.10.2

XP_006538607.1

EC 2.7.10.2

XP_006538608.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010208.4 → NP_034338.3 tyrosine-protein kinase Fgr

See identical proteins and their annotated locations for NP_034338.3

Status: VALIDATED

Source sequence(s)

AI661913, AK038141, AK155902, BY204076

Consensus CDS

CCDS18739.1

UniProtKB/Swiss-Prot

P14234, Q61404, Q8BGM0

UniProtKB/TrEMBL

Q6GTF2

Related

ENSMUSP00000030693.7, ENSMUST00000030693.13

Conserved Domains (3) summary

cd10367
Location:128 → 228

SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr

cl17036
Location:68 → 125

SH3; Src Homology 3 domain superfamily

cl21453
Location:255 → 502

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

132701406..132729204

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538544.5 → XP_006538607.1 tyrosine-protein kinase Fgr isoform X1

See identical proteins and their annotated locations for XP_006538607.1

UniProtKB/Swiss-Prot

P14234, Q61404, Q8BGM0

UniProtKB/TrEMBL

Q6GTF2

Conserved Domains (3) summary

cd10367
Location:128 → 228

SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr

cl17036
Location:68 → 125

SH3; Src Homology 3 domain superfamily

cl21453
Location:255 → 502

PKc_like; Protein Kinases, catalytic domain
XM_006538545.5 → XP_006538608.1 tyrosine-protein kinase Fgr isoform X1

See identical proteins and their annotated locations for XP_006538608.1

UniProtKB/Swiss-Prot

P14234, Q61404, Q8BGM0

UniProtKB/TrEMBL

Q6GTF2

Related

ENSMUSP00000128411.2, ENSMUST00000171223.2

Conserved Domains (3) summary

cd10367
Location:128 → 228

SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr

cl17036
Location:68 → 125

SH3; Src Homology 3 domain superfamily

cl21453
Location:255 → 502

PKc_like; Protein Kinases, catalytic domain