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    Prim1 DNA primase, p49 subunit [ Mus musculus (house mouse) ]

    Gene ID: 19075, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Prim1provided by MGI
    Official Full Name
    DNA primase, p49 subunitprovided by MGI
    Primary source
    MGI:MGI:97757
    See related
    Ensembl:ENSMUSG00000025395 AllianceGenome:MGI:97757
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables DNA primase activity. Involved in DNA replication initiation and DNA replication, synthesis of primer. Part of alpha DNA polymerase:primase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PRIM1 (DNA primase subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 29.4), CNS E11.5 (RPKM 24.3) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prim1 in Genome Data Viewer
    Location:
    10 76.39 cM; 10 D3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127851084..127865899)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128015215..128030030)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 6 Neighboring gene STARR-positive B cell enhancer ABC_E8376 Neighboring gene STARR-positive B cell enhancer ABC_E9812 Neighboring gene small nuclear ribonucleoprotein D2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28254 Neighboring gene nascent polypeptide-associated complex alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E5198 Neighboring gene STARR-positive B cell enhancer ABC_E10658 Neighboring gene prostaglandin E synthase 3 Neighboring gene predicted gene, 47438

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse primase p49 subunit molecular cloning indicates conserved and divergent regions. Prussak CE, et al. J Biol Chem, 1989 Mar 25. PMID 2925677
    2. Identification of the nuclear localization signal of mouse DNA primase: nuclear transport of p46 subunit is facilitated by interaction with p54 subunit. Mizuno T, et al. J Cell Sci, 1996 Nov. PMID 8937981
    3. Physical mapping of the genes for three components of the mouse DNA replication complex: polymerase alpha to the X chromosome, primase p49 subunit to chromosome 10, and primase p58 subunit to chromosome 1. Adler DA, et al. Genomics, 1991 Apr. PMID 2037291
    4. Molecular cloning of the cDNAs for the four subunits of mouse DNA polymerase alpha-primase complex and their gene expression during cell proliferation and the cell cycle. Miyazawa H, et al. J Biol Chem, 1993 Apr 15. PMID 8463324
    5. Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12. Shiratori A, et al. Genomics, 1995 Jul 20. PMID 8530050

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107288

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA primase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA primase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA primase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication, synthesis of primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication, synthesis of primer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication, synthesis of primer ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha DNA polymerase:primase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of alpha DNA polymerase:primase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of alpha DNA polymerase:primase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA primase small subunit
    Names
    DNA primase 49 kDa subunit
    p49
    NP_032947.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008921.2 → NP_032947.1  DNA primase small subunit

      See identical proteins and their annotated locations for NP_032947.1

      Status: PROVISIONAL

      Source sequence(s)
      AC131120
      Consensus CDS
      CCDS36086.1
      UniProtKB/Swiss-Prot
      P20664
      UniProtKB/TrEMBL
      Q3UZF0, Q5FW94
      Related
      ENSMUSP00000026461.8, ENSMUST00000026461.8
      Conserved Domains (1) summary
      cd04860
      Location:26 → 343
      AE_Prim_S; AE_Prim_S: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. Primases are DNA-dependent RNA polymerases which synthesis the short RNA primers required for DNA replication. In addition to its ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127851084..127865899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20664.1 GenPept UniProtKB/Swiss-Prot:P20664

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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