Azgp1 alpha-2-glycoprotein 1, zinc [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Azgp1provided by MGI
Official Full Name: alpha-2-glycoprotein 1, zincprovided by MGI
Primary source: MGI:MGI:103163
See related: Ensembl:ENSMUSG00000037053 AllianceGenome:MGI:103163
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zag
Summary: Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; detection of chemical stimulus involved in sensory perception of bitter taste; and positive regulation of T cell mediated cytotoxicity. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and liver and biliary system. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human AZGP1 (alpha-2-glycoprotein 1, zinc-binding). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 435.9) and liver E18 (RPKM 299.4) See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.92 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137979783..137988495)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137981521..137990233)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AZGP1 Aggravates Macrophage M1 Polarization and Pyroptosis in Periodontitis.
Title: AZGP1 Aggravates Macrophage M1 Polarization and Pyroptosis in Periodontitis.
Adipokine ZAG Alters Depression-Like Behavior by Regulating Oxidative Stress in Hippocampus.
Title: Adipokine ZAG Alters Depression-Like Behavior by Regulating Oxidative Stress in Hippocampus.
Zinc-alpha2-glycoprotein promotes skeletal muscle lipid metabolism in cold-stressed mice.
Title: Zinc-α2-glycoprotein promotes skeletal muscle lipid metabolism in cold-stressed mice.
Adipokine zinc-alpha2-glycoprotein alleviates lipopolysaccharide-induced inflammatory responses through the beta3-AR/PKA/CREB pathway.
Title: Adipokine zinc-α2-glycoprotein alleviates lipopolysaccharide-induced inflammatory responses through the β3-AR/PKA/CREB pathway.
Study in non-alcoholic fatty liver disease (NAFLD) patients, mouse model, and human LO2 cells revealed that AZGP1 levels were significantly decreased in liver tissues of NAFLD patients and mice. AZGP1 alleviated NAFLD by blocking TNF-alpha-mediated inflammation and intracellular lipid deposition, promoting proliferation, and inhibiting apoptosis in LO2 cells.
Title: Zinc-α2-glycoprotein 1 attenuates non-alcoholic fatty liver disease by negatively regulating tumour necrosis factor-α.
Studied the novel role of zinc-alpha-2-glycoprotein (ZAG) in regulating hepatic steatosis, insulin resistance, and inflammation in the fatty liver in an obese mouse model.
Title: Zinc alpha2 glycoprotein protects against obesity-induced hepatic steatosis.
A role of Azgp1 in lipid metabolism, in particular in mammary gland, during lactation.Azgp1 role in the expression of genes in the adipose tissue and liver.
Title: Effects of Azgp1(-/-)on mammary gland, adipose tissue and liver gene expression and milk lipid composition in lactating mice.
ZAG may be beneficial for preventing high-fat-diet-induced hepatic lipid metabolic disorders.
Title: Effects of Zinc Alpha2 Glycoprotein on Lipid Metabolism of Liver in High-Fat Diet-Induced Obese Mice.
Zinc alpha2 glycoprotein promotes browning in adipocytes.
Title: Zinc alpha2 glycoprotein promotes browning in adipocytes.
AZGP1 is a negative regulator of fibrosis progression in kidney and heart
Title: Zinc-α2-Glycoprotein Exerts Antifibrotic Effects in Kidney and Heart.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D21059 (e-PCR)
- UniSTS:163375

Azgp1 (e-PCR), detects polymorphism
- UniSTS:141143

Azgp1 (e-PCR), detects polymorphism
- UniSTS:141144

PMC356979P1 (e-PCR)
- UniSTS:273287

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of multicellular organism growth	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc-alpha-2-glycoprotein

Names: major histocompatibility complex class I-like protein; zn-alpha-2-GP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.