Cpne1 copine I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cpne1provided by MGI
Official Full Name: copine Iprovided by MGI
Primary source: MGI:MGI:2386621
See related: Ensembl:ENSMUSG00000074643 AllianceGenome:MGI:2386621
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA4108; 1810028N16Rik
Summary: This gene encodes a protein that contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Its activity is also upregulated in mouse embryos. This gene and the gene for RNA binding motif protein 12 overlap at map location 2 H2. Two alternatively spliced variants that encode the same isoform have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thymus adult (RPKM 29.7), limb E14.5 (RPKM 24.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 77.34 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (155913765..155953847, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (156071841..156111965, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing of CPNE1-TRAF2 Axis Restrains the Development of Pancreatic Cancer.
Title: Silencing of CPNE1-TRAF2 Axis Restrains the Development of Pancreatic Cancer.
CPNE1 mediates glycolysis and metastasis of breast cancer through activation of PI3K/AKT/HIF-1alpha signaling.
Title: CPNE1 mediates glycolysis and metastasis of breast cancer through activation of PI3K/AKT/HIF-1α signaling.
CPNE1 regulates myogenesis through the PERK-eIF2alpha pathway mediated by endoplasmic reticulum stress.
Title: CPNE1 regulates myogenesis through the PERK-eIF2α pathway mediated by endoplasmic reticulum stress.
Methylprednisolone Attenuates Lipopolysaccharide-Induced Sepsis by Modulating the Small Nucleolar RNA Host Gene 5/Copine 1 Pathway.
Title: Methylprednisolone Attenuates Lipopolysaccharide-Induced Sepsis by Modulating the Small Nucleolar RNA Host Gene 5/Copine 1 Pathway.
These data demonstrate that CPNE1 plays a key role in the regulation of neural stem cell functions through the activation of AKT-mTOR signaling pathway during brain development.
Title: Copine1 regulates neural stem cell functions during brain development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB099775 (e-PCR)
- UniSTS:207433

AI852903 (e-PCR)
- UniSTS:164188

REN58605 (e-PCR)
- UniSTS:383405

REN58606 (e-PCR)
- UniSTS:383406

17.MMHAP71FRF8.seq (e-PCR)
- UniSTS:123353

ECD04598 (e-PCR)
- UniSTS:285670

UniSTS:479221 (e-PCR)
- UniSTS:479221

Rbm12 (e-PCR), detects polymorphism
- UniSTS:479221

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: copine-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_170588.4 → NP_733467.1 copine-1

See identical proteins and their annotated locations for NP_733467.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL833786

Consensus CDS

CCDS16960.1

UniProtKB/Swiss-Prot

Q8C166, Q925K4, Q925K5

UniProtKB/TrEMBL

Q3U893

Related

ENSMUSP00000105237.3, ENSMUST00000109608.9

Conserved Domains (3) summary

cd04047
Location:137 → 244

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:6 → 123

C2A_Copine; C2 domain first repeat in Copine

cd01459
Location:250 → 507

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
NM_170590.4 → NP_733469.1 copine-1

See identical proteins and their annotated locations for NP_733469.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL833786

Consensus CDS

CCDS16960.1

UniProtKB/Swiss-Prot

Q8C166, Q925K4, Q925K5

UniProtKB/TrEMBL

Q3U893

Related

ENSMUSP00000105236.3, ENSMUST00000109607.10

Conserved Domains (3) summary

cd04047
Location:137 → 244

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:6 → 123

C2A_Copine; C2 domain first repeat in Copine

cd01459
Location:250 → 507

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...