FSTL4 follistatin like 4 [Gallus gallus (chicken)] - Gene

Summary

Symbol: FSTL4provided by CGNC
Full Name: follistatin like 4provided by CGNC
Primary source: CGNC:49196
See related: Ensembl:ENSGALG00010015972
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	13	NC_052544.1 (15845754..16032315)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	13	NC_052585.1 (15826540..16043958)

Chromosome 13 - NC_052544.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: follistatin-related protein 4

Names: D/Bsp120I#1 subtype A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204502.3 → NP_989833.1 follistatin-related protein 4 precursor

See identical proteins and their annotated locations for NP_989833.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000256

UniProtKB/TrEMBL

A0A8V0YW54, Q71SY9

Related

ENSGALP00010022275.1, ENSGALT00010038498.1

Conserved Domains (8) summary

cd00096
Location:266 → 322

Ig; Immunoglobulin domain

cd05736
Location:357 → 432

Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins

smart00410
Location:257 → 338

IG_like; Immunoglobulin like

COG3391
Location:495 → 702

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00051
Location:179 → 242

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00104
Location:94 → 134

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam07679
Location:340 → 429

I-set; Immunoglobulin I-set domain

pfam13499
Location:179 → 241

EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

15845754..16032315

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015293992.3 → XP_015149478.3 follistatin-related protein 4 isoform X2

UniProtKB/TrEMBL

A0A8V0YW54, A7LAP2

Conserved Domains (6) summary

COG3391
Location:504 → 711

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00051
Location:179 → 242

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00104
Location:94 → 134

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00096
Location:267 → 322

Ig; Immunoglobulin domain

cd05736
Location:340 → 432

IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl29726
Location:689 → 752

Pectate_lyase22; Oligogalacturonate lyase
XM_025154798.3 → XP_025010566.2 follistatin-related protein 4 isoform X5

UniProtKB/TrEMBL

A0A8V0YW54

Conserved Domains (6) summary

smart00408
Location:420 → 486

IGc2; Immunoglobulin C-2 Type

COG3391
Location:571 → 778

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00051
Location:246 → 309

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00104
Location:161 → 201

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00096
Location:424 → 428

Ig; Ig strand B [structural motif]

cl29726
Location:756 → 819

Pectate_lyase22; Oligogalacturonate lyase
XM_025154799.3 → XP_025010567.2 follistatin-related protein 4 isoform X6

UniProtKB/TrEMBL

A0A8V0YW54

Conserved Domains (6) summary

smart00408
Location:420 → 486

IGc2; Immunoglobulin C-2 Type

COG3391
Location:562 → 769

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00051
Location:246 → 309

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00104
Location:161 → 201

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00096
Location:424 → 428

Ig; Ig strand B [structural motif]

cl29726
Location:747 → 810

Pectate_lyase22; Oligogalacturonate lyase
XM_015293991.4 → XP_015149477.3 follistatin-related protein 4 isoform X2

UniProtKB/TrEMBL

A0A8V0YW54, A7LAP2

Related

ENSGALP00010022272.1, ENSGALT00010038493.1

Conserved Domains (6) summary

COG3391
Location:504 → 711

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00051
Location:179 → 242

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00104
Location:94 → 134

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00096
Location:267 → 322

Ig; Immunoglobulin domain

cd05736
Location:340 → 432

IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl29726
Location:689 → 752

Pectate_lyase22; Oligogalacturonate lyase
XM_040646843.2 → XP_040502777.1 follistatin-related protein 4 isoform X2

UniProtKB/TrEMBL

A0A8V0YW54, A7LAP2

Conserved Domains (6) summary

COG3391
Location:504 → 711

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00051
Location:179 → 242

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00104
Location:94 → 134

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00096
Location:267 → 322

Ig; Immunoglobulin domain

cd05736
Location:340 → 432

IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cl29726
Location:689 → 752

Pectate_lyase22; Oligogalacturonate lyase
XM_040646842.2 → XP_040502776.1 follistatin-related protein 4 isoform X1

UniProtKB/TrEMBL

A0A8V0YW54

Conserved Domains (6) summary

smart00408
Location:394 → 460

IGc2; Immunoglobulin C-2 Type

COG3391
Location:545 → 752

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00051
Location:220 → 283

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00104
Location:135 → 175

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00096
Location:380 → 385

Ig; Ig strand A [structural motif]

cl29726
Location:730 → 793

Pectate_lyase22; Oligogalacturonate lyase
XM_015293988.4 → XP_015149474.3 follistatin-related protein 4 isoform X3

UniProtKB/TrEMBL

A0A8V0YU51

Conserved Domains (6) summary

smart00408
Location:436 → 502

IGc2; Immunoglobulin C-2 Type

COG3391
Location:587 → 794

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00051
Location:262 → 325

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00104
Location:177 → 217

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00096
Location:422 → 427

Ig; Ig strand A [structural motif]

cl29726
Location:772 → 835

Pectate_lyase22; Oligogalacturonate lyase
XM_040646840.2 → XP_040502774.1 follistatin-related protein 4 isoform X4

UniProtKB/TrEMBL

A0A8V0YU51

Related

ENSGALP00010022266.1, ENSGALT00010038486.1

Conserved Domains (6) summary

smart00408
Location:436 → 502

IGc2; Immunoglobulin C-2 Type

COG3391
Location:578 → 785

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00051
Location:262 → 325

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00104
Location:177 → 217

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00096
Location:422 → 427

Ig; Ig strand A [structural motif]

cl29726
Location:763 → 826

Pectate_lyase22; Oligogalacturonate lyase

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

15826540..16043958

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046926804.1 → XP_046782760.1 follistatin-related protein 4 isoform X2

UniProtKB/TrEMBL

A0A8V0YW54
XM_046926800.1 → XP_046782756.1 follistatin-related protein 4 isoform X7

UniProtKB/TrEMBL

A0A8V0YW54
XM_046926801.1 → XP_046782757.1 follistatin-related protein 4 isoform X8

UniProtKB/TrEMBL

A0A8V0YW54
XM_046926803.1 → XP_046782759.1 follistatin-related protein 4 isoform X2

UniProtKB/TrEMBL

A0A8V0YW54
XM_046926805.1 → XP_046782761.1 follistatin-related protein 4 isoform X2

UniProtKB/TrEMBL

A0A8V0YW54
XM_046926802.1 → XP_046782758.1 follistatin-related protein 4 isoform X1

UniProtKB/TrEMBL

A0A8V0YW54