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    EBF1 EBF transcription factor 1 [ Gallus gallus (chicken) ]

    Gene ID: 395512, updated on 3-Dec-2024

    Summary

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    Official Symbol
    EBF1provided by CGNC
    Official Full Name
    EBF transcription factor 1provided by CGNC
    Primary source
    CGNC:49357
    See related
    Ensembl:ENSGALG00010012921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    EBF
    Orthologs
    human mouse all
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    Genomic context

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    See EBF1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (10287788..10551209)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (10290345..10553851)

    Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene ubiquitin like domain containing CTD phosphatase 1 Neighboring gene ring finger protein 145 Neighboring gene uncharacterized LOC101749832 Neighboring gene clathrin interactor 1 Neighboring gene LSM11, U7 small nuclear RNA associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and function of Ebf1 gene during chondrogenesis in chick embryo limb buds. El-Magd MA, et al. Gene, 2021 Nov 30. PMID 34384862
    2. Regulation of chick early B-cell factor-1 gene expression in feather development. El-Magd MA, et al. Acta Histochem, 2014 May. PMID 24365066
    3. Shh regulates chick Ebf1 gene expression in somite development. El-Magd MA, et al. Gene, 2015 Jan 1. PMID 25455103
    4. EBF1 acts as a powerful repressor of Blimp-1 gene expression in immature B cells. Kikuchi H, et al. Biochem Biophys Res Commun, 2012 Jun 15. PMID 22634309
    5. Ebf gene function is required for coupling neuronal differentiation and cell cycle exit. Garcia-Dominguez M, et al. Development, 2003 Dec. PMID 14573522

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression and function of Ebf1 gene during chondrogenesis in chick embryo limb buds.
      Title: Expression and function of Ebf1 gene during chondrogenesis in chick embryo limb buds.
    2. early B-cell factor-1 expression in the feather bud is under the control of Sonic Hedgehog and Bmp4 signals and that expression may play a role in the normal development of feathers
      Title: Regulation of chick early B-cell factor-1 gene expression in feather development.
    3. cEbf1 gene is considered as a medial sclerotome marker, downstream to and regulated by the notochord derived Shh, which may be functionally involved in somitogenesis
      Title: Shh regulates chick Ebf1 gene expression in somite development.
    4. Ectopic expression of retinoic acid (RA) led to up-regulation of cEbf2, 3 but did not change cEbf1 expression in somites. Expectedly, inhibition of RA by disulfiram resulted in downregulation of cEbf2, 3, but did not change cEbf1 expression in somites. The same RA gain and loss of function experiments did not change cEbf1-3 expression in pharyngeal arches.
      Title: The effect of RA on the chick Ebf1-3 genes expression in somites and pharyngeal arches.
    5. GCN5 binds to the 5'-flanking region of the chicken PRKCQ gene and acetylates histone H3, and EBF1 binds to the 5'-flanking region of the gene surrounding putative EBF1 binding motifs.
      Title: Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells.
    6. This is the first report on a novel EBF1 function in immature B cells as a powerful repressor of Blimp-1 gene expression.
      Title: EBF1 acts as a powerful repressor of Blimp-1 gene expression in immature B cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor COE1
    Names
    early B-cell factor 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001397656.1 → NP_001384585.1  transcription factor COE1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000256
      UniProtKB/TrEMBL
      A0A8V0YHL9, Q9I9C6
      Related
      ENSGALP00010018034.1, ENSGALT00010031026.1
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    2. NM_001397657.1 → NP_001384586.1  transcription factor COE1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000256
      UniProtKB/TrEMBL
      Q9I9C6
      Conserved Domains (3) summary
      cd01175
      Location:255 → 339
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:340 → 383
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    3. NM_001397658.1 → NP_001384587.1  transcription factor COE1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000256
      UniProtKB/TrEMBL
      Q9I9C6
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    4. NM_001397659.1 → NP_001384588.1  transcription factor COE1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000256
      UniProtKB/TrEMBL
      A0A8V0YHL3
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    5. NM_204752.3 → NP_990083.2  transcription factor COE1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000256
      UniProtKB/TrEMBL
      Q9I9C6
      Conserved Domains (3) summary
      cd01175
      Location:262 → 346
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:347 → 390
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      10287788..10551209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015293734.4 → XP_015149220.1  transcription factor COE1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YHL3, F1N9Q3
      Related
      ENSGALP00010018031.1, ENSGALT00010031020.1
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    2. XM_015293735.4 → XP_015149221.1  transcription factor COE1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YHL3
      Related
      ENSGALP00010018029.1, ENSGALT00010031018.1
      Conserved Domains (3) summary
      cd01175
      Location:262 → 346
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:347 → 390
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    3. XM_015293736.4 → XP_015149222.1  transcription factor COE1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YHL3
      Conserved Domains (3) summary
      cd01175
      Location:255 → 339
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:340 → 383
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    4. XM_015293740.4 → XP_015149226.1  transcription factor COE1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YHL3
      Conserved Domains (3) summary
      cd11606
      Location:16 → 217
      COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
      cd01175
      Location:233 → 317
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16423
      Location:318 → 361
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    5. XM_015293741.4 → XP_015149227.1  transcription factor COE1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YHL3
      Conserved Domains (3) summary
      cd11606
      Location:16 → 217
      COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
      cd01175
      Location:232 → 316
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16423
      Location:317 → 360
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      10290345..10553851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046926826.1 → XP_046782782.1  transcription factor COE1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YHL3, F1N9Q3

    2. XM_046926827.1 → XP_046782783.1  transcription factor COE1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YHL3

    3. XM_046926828.1 → XP_046782784.1  transcription factor COE1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YHL3

    4. XM_046926829.1 → XP_046782785.1  transcription factor COE1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YHL3

    5. XM_046926830.1 → XP_046782786.1  transcription factor COE1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YHL3
    Nucleotide Protein Strain
    Heading Accession and Version

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