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    VAV3 vav 3 guanine nucleotide exchange factor [ Gallus gallus (chicken) ]

    Gene ID: 373939, updated on 3-Dec-2024

    Summary

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    Official Symbol
    VAV3provided by CGNC
    Official Full Name
    vav 3 guanine nucleotide exchange factorprovided by CGNC
    Primary source
    CGNC:1353
    See related
    Ensembl:ENSGALG00010011932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See VAV3 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (1002266..1150420, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (1008097..1156631, complement)

    Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene netrin G1 Neighboring gene uncharacterized LOC112532929 Neighboring gene uncharacterized LOC112532928 Neighboring gene uncharacterized LOC107053912 Neighboring gene protein FAM102B-like Neighboring gene solute carrier family 25 member 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tyrosine phosphorylation of 3BP2 is indispensable for the interaction with VAV3 in chicken DT40 cells. Chihara K, et al. Exp Cell Res, 2014 Mar 10. PMID 24406398
    2. Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. Inabe K, et al. J Exp Med, 2002 Jan 21. PMID 11805146, Free PMC Article
    3. Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. Weber M, et al. J Exp Med, 2008 Apr 14. PMID 18362175, Free PMC Article
    4. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 3BP2 is involved in the activation of Rac1 through the regulation of Vav3 by Syk-dependent phosphorylation of Tyr(426) following BCR stimulation.
      Title: Tyrosine phosphorylation of 3BP2 is indispensable for the interaction with VAV3 in chicken DT40 cells.
    2. A key role for phospholipase C-gamma2 (PLCgamma2), Vav, B cell linker, and Bruton's tyrosine kinase in the formation of highly coordinated "microsignalosomes," , is identified.[
      Title: Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor VAV3
    Names
    vav 3 oncogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_206863.4 → NP_996745.1  guanine nucleotide exchange factor VAV3

      See identical proteins and their annotated locations for NP_996745.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000237
      UniProtKB/TrEMBL
      A0A8V0YD40, Q8UUX6
      Related
      ENSGALP00010016410.1, ENSGALT00010028575.1
      Conserved Domains (7) summary
      cd10407
      Location:665 → 767
      SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
      cd11978
      Location:790 → 845
      SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
      cd11981
      Location:595 → 656
      SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
      cd00029
      Location:514 → 561
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:383 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00307
      Location:2 → 115
      CH; Calponin homology (CH) domain
      pfam00621
      Location:196 → 370
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      1002266..1150420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025152727.3 → XP_025008495.1  guanine nucleotide exchange factor VAV3 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YFB5
      Related
      ENSGALP00010016416.1, ENSGALT00010028584.1
      Conserved Domains (7) summary
      cd10407
      Location:636 → 738
      SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
      cd11978
      Location:789 → 844
      SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
      cd11981
      Location:566 → 627
      SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
      cd00029
      Location:485 → 532
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:193 → 363
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:363 → 477
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    2. XM_015290228.4 → XP_015145714.1  guanine nucleotide exchange factor VAV3 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YD40
      Conserved Domains (7) summary
      cd10407
      Location:664 → 766
      SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
      cd11978
      Location:817 → 872
      SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
      cd11981
      Location:594 → 655
      SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
      cd00029
      Location:514 → 561
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:383 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00307
      Location:2 → 115
      CH; Calponin homology (CH) domain
      pfam00621
      Location:196 → 370
      RhoGEF; RhoGEF domain

    3. XM_015290227.4 → XP_015145713.1  guanine nucleotide exchange factor VAV3 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y6W5, A0A8V0YD40
      Related
      ENSGALP00010016408.1, ENSGALT00010028570.1
      Conserved Domains (7) summary
      cd10407
      Location:665 → 767
      SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
      cd11978
      Location:818 → 873
      SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
      cd11981
      Location:595 → 656
      SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
      cd00029
      Location:514 → 561
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:383 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00307
      Location:2 → 115
      CH; Calponin homology (CH) domain
      pfam00621
      Location:196 → 370
      RhoGEF; RhoGEF domain

    4. XM_046944196.1 → XP_046800152.1  guanine nucleotide exchange factor VAV3 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YD49

    5. XM_040704448.2 → XP_040560382.1  guanine nucleotide exchange factor VAV3 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YD49
      Related
      ENSGALP00010016395.1, ENSGALT00010028557.1
      Conserved Domains (6) summary
      smart00109
      Location:427 → 475
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd10407
      Location:578 → 680
      SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
      cd11978
      Location:731 → 786
      SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
      cd11981
      Location:508 → 569
      SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
      cd00160
      Location:106 → 282
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:296 → 419
      PH_Vav; Vav pleckstrin homology (PH) domain

    6. XM_025152728.3 → XP_025008496.2  guanine nucleotide exchange factor VAV3 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YD35, A0A8V0YD40
      Related
      ENSGALP00010016405.1, ENSGALT00010028567.1
      Conserved Domains (6) summary
      smart00109
      Location:514 → 562
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd10407
      Location:665 → 767
      SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
      cd11981
      Location:595 → 656
      SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
      cd00160
      Location:193 → 369
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:383 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      1008097..1156631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046922179.1 → XP_046778135.1  guanine nucleotide exchange factor VAV3 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YFB5

    2. XM_046922178.1 → XP_046778134.1  guanine nucleotide exchange factor VAV3 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YD40

    3. XM_046922177.1 → XP_046778133.1  guanine nucleotide exchange factor VAV3 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y6W5, A0A8V0YD40

    4. XM_046922182.1 → XP_046778138.1  guanine nucleotide exchange factor VAV3 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YD49

    5. XM_046922181.1 → XP_046778137.1  guanine nucleotide exchange factor VAV3 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YD49

    6. XM_046922180.1 → XP_046778136.1  guanine nucleotide exchange factor VAV3 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YD40
    Nucleotide Protein Strain
    Heading Accession and Version

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