XRCC5 X-ray repair cross complementing 5 [Gallus gallus (chicken)] - Gene

Summary

Symbol: XRCC5provided by CGNC
Full Name: X-ray repair cross complementing 5provided by CGNC
Primary source: CGNC:8733
See related: Ensembl:ENSGALG00010021235
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	7	NC_052538.1 (23121282..23165084, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	7	NC_052579.1 (23040108..23084072, complement)

Chromosome 7 - NC_052538.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KU70 and DNA-PKcs unexpectedly function together during the induction of apoptosis.
Title: KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation.

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables telomeric DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to X-ray	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to gamma radiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in double-strand break repair via nonhomologous end joining	IEA Inferred from Electronic Annotation more info	PubMed
involved_in telomere maintenance	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of Ku70:Ku80 complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: X-ray repair cross-complementing protein 5

Names: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa)

XP_040532570.1

EC 3.6.4.-

XP_040532571.2

EC 3.6.4.-

XP_040559816.2

EC 3.6.4.-

XP_046778102.1

EC 3.6.4.-

XP_046778103.1

EC 3.6.4.-

XP_046799672.1

EC 3.6.4.-

XP_046799673.1

EC 3.6.4.-

XP_422072.5

EC 3.6.4.-

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

23121282..23165084 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_422072.8 → XP_422072.5 X-ray repair cross-complementing protein 5 isoform X2

UniProtKB/TrEMBL

A0A8V0ZBK8, A0A8V0ZIP8

Related

ENSGALP00010030666.1, ENSGALT00010051475.1

Conserved Domains (2) summary

cd00873
Location:281 → 579

KU80; Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...

cl00057
Location:45 → 209

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_046943716.1 → XP_046799672.1 X-ray repair cross-complementing protein 5 isoform X1

UniProtKB/TrEMBL

A0A8V0ZBK8
XM_046943717.1 → XP_046799673.1 X-ray repair cross-complementing protein 5 isoform X3

UniProtKB/TrEMBL

A0A8V0ZBK8
XM_040703882.2 → XP_040559816.2 X-ray repair cross-complementing protein 5 isoform X4

UniProtKB/TrEMBL

A0A8V0ZBK8

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

23040108..23084072 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040676636.2 → XP_040532570.1 X-ray repair cross-complementing protein 5 isoform X2

UniProtKB/TrEMBL

A0A8V0ZBK8

Conserved Domains (2) summary

cd00873
Location:281 → 579

KU80; Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...

cl00057
Location:45 → 209

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_046922146.1 → XP_046778102.1 X-ray repair cross-complementing protein 5 isoform X1

UniProtKB/TrEMBL

A0A8V0ZBK8
XM_046922147.1 → XP_046778103.1 X-ray repair cross-complementing protein 5 isoform X3

UniProtKB/TrEMBL

A0A8V0ZBK8
XM_040676637.2 → XP_040532571.2 X-ray repair cross-complementing protein 5 isoform X4

UniProtKB/TrEMBL

A0A8V0ZBK8