CASP3 caspase 3 [Gallus gallus (chicken)] - Gene

Summary

Symbol: CASP3provided by CGNC
Full Name: caspase 3provided by CGNC
Primary source: CGNC:8080
See related: Ensembl:ENSGALG00010007067
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: caspase-3
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (39069163..39084205)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (39016790..39032200)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mRNA expression was higher in Bax and Caspase-3, and lower in Bcl-2 of the 300, 600 and 900 mg/kg groups. SOD, CAT and GSH-Px activities, ability to inhibit hydroxyl radical, and GSH contents were decreased, and MDA contents were increased in all groups.
Title: The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers.
Finally, the inhibition of chicken caspase activity in avian reovirus-infected cells does not diminish virus gene expression and replication, but drastically reduces muNS processing and the release and dissemination of progeny viral particles.
Title: Avian reovirus-triggered apoptosis enhances both virus spread and the processing of the viral nonstructural muNS protein.
Data suggest that lymphocyte apoptosis in the cecal tonsil of broilers was mediated by direct effects of fluoride on the expression of Bcl-2, Bax, and caspase-3: [bax]
Title: Dietary high fluorine induces apoptosis and alters Bcl-2, Bax, and caspase-3 protein expression in the cecal tonsil lymphocytes of broilers.
Results suggest that both caspase-1 and -3 are responsible for the cleavage at the C terminus of connexin 50 (Cx50) during lens development.
Title: Developmental truncations of connexin 50 by caspases adaptively regulate gap junctions/hemichannels and protect lens cells against ultraviolet radiation.
the IGF-1R/NFkappaB cell survival signal is a crucial regulator of the level of caspase-3 activation for its non-apoptotic function in signaling cell differentiation.
Title: Insulin-like growth factor receptor-1 and nuclear factor κB are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation.
caspase-8 and caspase-3 are activated during pre-mature lymphocyte apoptosis
Title: GCN5 and BCR signalling collaborate to induce pre-mature B cell apoptosis through depletion of ICAD and IAP2 and activation of caspase activities.
Comparison of activated caspase-3 detection methods in the gentamicin-treated chick cochlea.
Title: Comparison of activated caspase detection methods in the gentamicin-treated chick cochlea.
Avian DT40 pre-B-cells exposed to TCDD are susceptible to apoptosis, likely through activation of executioner caspase 3.
Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin elicits aryl hydrocarbon receptor-mediated apoptosis in the avian DT40 pre-B-cell line through activation of caspases 9 and 3.
It is concluded that during hypertrophy, the change in membrane potential, the increased binding of a pro-apoptotic protein to mitochondria, and the activation of caspase-3 serve to prime cells for apoptosis.
Title: Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: caspase-3

Names: caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease

NP_990056.1

EC 3.4.22.56

XP_015131608.1

EC 3.4.22.56

XP_015131609.1

EC 3.4.22.56

XP_046771431.1

EC 3.4.22.56

XP_046771432.1

EC 3.4.22.56

XP_046771433.1

EC 3.4.22.56

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204725.2 → NP_990056.1 caspase-3

See identical proteins and their annotated locations for NP_990056.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000073

UniProtKB/TrEMBL

A0A8V0XTY2, O93417

Related

ENSGALP00010009453.1, ENSGALT00010016785.1

Conserved Domains (1) summary

cd00032
Location:45 → 282

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

39069163..39084205

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015276122.4 → XP_015131608.1 caspase-3 isoform X1

UniProtKB/TrEMBL

A0A8V0XTY2, O93417

Related

ENSGALP00010009451.1, ENSGALT00010016780.1

Conserved Domains (1) summary

cd00032
Location:45 → 282

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
XM_015276123.4 → XP_015131609.1 caspase-3 isoform X1

UniProtKB/TrEMBL

A0A8V0XTY2, O93417

Conserved Domains (1) summary

cd00032
Location:45 → 282

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...