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    CREM cAMP responsive element modulator [ Gallus gallus (chicken) ]

    Gene ID: 378903, updated on 3-Dec-2024

    Summary

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    Symbol
    CREMprovided by CGNC
    Full Name
    cAMP responsive element modulatorprovided by CGNC
    Primary source
    CGNC:49136
    See related
    Ensembl:ENSGALG00010004425
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    ICER
    Orthologs
    human mouse all
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    Genomic context

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    See CREM in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (12931761..12963477, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (12959698..12991338, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene gap junction protein delta 4 Neighboring gene cyclin Y Neighboring gene uncharacterized LOC107052602 Neighboring gene translation initiation factor IF-2-like Neighboring gene cullin 2 Neighboring gene par-3 family cell polarity regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ESTs from brain and testis of White Leghorn and red junglefowl: annotation, bioinformatic classification of unknown transcripts and analysis of expression levels. Savolainen P, et al. Cytogenet Genome Res, 2005. PMID 16093725
    2. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATF4-CREB1 transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP-responsive element modulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278132.1 → NP_001265061.1  cAMP-responsive element modulator isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BU485989, BX931695, BX934897, CN234043, CN235463
      Conserved Domains (2) summary
      cd14690
      Location:238 → 292
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:65 → 102
      pKID; pKID domain

    2. NM_001278133.2 → NP_001265062.1  cAMP-responsive element modulator isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the UTRs and coding region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAENSK010000036
      UniProtKB/TrEMBL
      F1N847
      Conserved Domains (2) summary
      cd14690
      Location:223 → 277
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:50 → 87
      pKID; pKID domain

    3. NM_001278134.1 → NP_001265063.1  cAMP-responsive element modulator isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the UTRs and coding region, compared to variant 1, including the lack of multiple 3' coding exons. It initiates translation at a downstream in-frame start codon. The encoded isoform (3) has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BX930447, CN232429
      Conserved Domains (1) summary
      pfam02173
      Location:50 → 87
      pKID; pKID domain

    4. NM_001278135.2 → NP_001265064.1  cAMP-responsive element modulator isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks multiple 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      JAENSK010000036
      Conserved Domains (1) summary
      cd14690
      Location:69 → 123
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    5. NM_204387.3 → NP_989718.2  cAMP-responsive element modulator isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the UTRs and coding region, compared to variant 1, including the lack of multiple 5' coding exons. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (4) is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      JAENSK010000036
      UniProtKB/TrEMBL
      Q7T3L4, R4GII4
      Conserved Domains (1) summary
      cd14690
      Location:69 → 123
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      12931761..12963477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046917410.1 → XP_046773366.1  cAMP-responsive element modulator isoform X4

    2. XM_015281264.4 → XP_015136750.1  cAMP-responsive element modulator isoform X3

      UniProtKB/TrEMBL
      F1N847
      Conserved Domains (2) summary
      cd14690
      Location:223 → 277
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:50 → 87
      pKID; pKID domain

    3. XM_015281263.4 → XP_015136749.1  cAMP-responsive element modulator isoform X2

      Conserved Domains (2) summary
      cd14690
      Location:238 → 292
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:65 → 102
      pKID; pKID domain

    4. XM_015281262.4 → XP_015136748.1  cAMP-responsive element modulator isoform X1

      UniProtKB/TrEMBL
      A0A1D5PT13
      Related
      ENSGALP00010006044.1, ENSGALT00010010339.1
      Conserved Domains (2) summary
      cd14690
      Location:238 → 292
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:65 → 102
      pKID; pKID domain

    5. XM_046917407.1 → XP_046773363.1  cAMP-responsive element modulator isoform X1

      UniProtKB/TrEMBL
      A0A1D5PT13

    6. XM_046917416.1 → XP_046773372.1  cAMP-responsive element modulator isoform X5

    7. XM_046917423.1 → XP_046773379.1  cAMP-responsive element modulator isoform X6

      UniProtKB/TrEMBL
      Q7T3L4, R4GII4

    8. XM_025147004.3 → XP_025002772.1  cAMP-responsive element modulator isoform X6

      UniProtKB/TrEMBL
      Q7T3L4, R4GII4
      Conserved Domains (1) summary
      cd14690
      Location:39 → 93
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      12959698..12991338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046910220.1 → XP_046766176.1  cAMP-responsive element modulator isoform X4

    2. XM_046910219.1 → XP_046766175.1  cAMP-responsive element modulator isoform X3

    3. XM_046910217.1 → XP_046766173.1  cAMP-responsive element modulator isoform X2

    4. XM_046910216.1 → XP_046766172.1  cAMP-responsive element modulator isoform X1

      UniProtKB/TrEMBL
      A0A1D5PT13

    5. XM_046910218.1 → XP_046766174.1  cAMP-responsive element modulator isoform X1

      UniProtKB/TrEMBL
      A0A1D5PT13

    6. XM_046910221.1 → XP_046766177.1  cAMP-responsive element modulator isoform X5

    7. XM_046910223.1 → XP_046766179.1  cAMP-responsive element modulator isoform X6

      UniProtKB/TrEMBL
      Q7T3L4, R4GII4

    8. XM_046910222.1 → XP_046766178.1  cAMP-responsive element modulator isoform X6

      UniProtKB/TrEMBL
      Q7T3L4, R4GII4
    Nucleotide Protein Strain
    Heading Accession and Version

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