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    CHAF1B chromatin assembly factor 1 subunit B [ Gallus gallus (chicken) ]

    Gene ID: 418514, updated on 3-Dec-2024

    Summary

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    Symbol
    CHAF1Bprovided by CGNC
    Full Name
    chromatin assembly factor 1 subunit Bprovided by CGNC
    Primary source
    CGNC:11983
    See related
    Ensembl:ENSGALG00010013082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    CAF1P60; CAF-1P60; CAF-Ip60; CAF-I p60
    Orthologs
    human mouse all
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    Genomic context

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    See CHAF1B in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (106754379..106775699)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (106843554..106864880)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene DOP1 leucine zipper like protein B Neighboring gene microRNA 7452 Neighboring gene uncharacterized LOC107055385 Neighboring gene MORC family CW-type zinc finger 4 Neighboring gene claudin 14 Neighboring gene uncharacterized LOC121107509

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Asf1 is required for viability and chromatin assembly during DNA replication in vertebrate cells. Sanematsu F, et al. J Biol Chem, 2006 May 12. PMID 16537536
    2. Essential role of chromatin assembly factor-1-mediated rapid nucleosome assembly for DNA replication and cell division in vertebrate cells. Takami Y, et al. Mol Biol Cell, 2007 Jan. PMID 17065558, Free PMC Article
    3. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion of CAF-1p150 and p60 led to delayed S-phase progression concomitant with slow DNA synthesis, followed by accumulation in late S/G2 phase.
      Title: Essential role of chromatin assembly factor-1-mediated rapid nucleosome assembly for DNA replication and cell division in vertebrate cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CAF-1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chromatin assembly factor 1 subunit B
    Names
    CAF-1 subunit B
    CAF-I 60 kDa subunit
    chromatin assembly factor 1, subunit B (p60)
    chromatin assembly factor I p60 subunit
    chromatin assembly factor-1p60

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008677.4 → NP_001008677.3  chromatin assembly factor 1 subunit B

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000020
      UniProtKB/Swiss-Prot
      Q5R1S9, Q5ZLM9
      Conserved Domains (3) summary
      sd00039
      Location:16 → 64
      7WD40; WD40 repeat [structural motif]
      pfam15512
      Location:388 → 555
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal
      cl29593
      Location:13 → 205
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001389297.2 → NP_001376226.1  chromatin assembly factor 1 subunit B

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000020
      UniProtKB/Swiss-Prot
      Q5R1S9, Q5ZLM9
      Related
      ENSGALP00010018308.1, ENSGALT00010031380.1
      Conserved Domains (3) summary
      sd00039
      Location:16 → 64
      7WD40; WD40 repeat [structural motif]
      pfam15512
      Location:388 → 555
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal
      cl29593
      Location:13 → 205
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      106754379..106775699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040698514.2 → XP_040554448.1  chromatin assembly factor 1 subunit B isoform X1

      UniProtKB/Swiss-Prot
      Q5R1S9, Q5ZLM9
      Related
      ENSGALP00010018296.1, ENSGALT00010031364.1
      Conserved Domains (3) summary
      sd00039
      Location:16 → 64
      7WD40; WD40 repeat [structural motif]
      pfam15512
      Location:388 → 555
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal
      cl29593
      Location:13 → 205
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_015299476.4 → XP_015154962.1  chromatin assembly factor 1 subunit B isoform X1

      UniProtKB/Swiss-Prot
      Q5R1S9, Q5ZLM9
      Conserved Domains (3) summary
      sd00039
      Location:16 → 64
      7WD40; WD40 repeat [structural motif]
      pfam15512
      Location:388 → 555
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal
      cl29593
      Location:13 → 205
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_005858988.2 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      106843554..106864880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046907908.1 → XP_046763864.1  chromatin assembly factor 1 subunit B isoform X1

      UniProtKB/Swiss-Prot
      Q5R1S9, Q5ZLM9

    2. XM_046907907.1 → XP_046763863.1  chromatin assembly factor 1 subunit B isoform X1

      UniProtKB/Swiss-Prot
      Q5R1S9, Q5ZLM9

    RNA

    1. XR_006932711.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5R1S9.1 GenPept UniProtKB/Swiss-Prot:Q5R1S9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials