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    NPL N-acetylneuraminate pyruvate lyase [ Gallus gallus (chicken) ]

    Gene ID: 429074, updated on 3-Dec-2024

    Summary

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    Symbol
    NPLprovided by CGNC
    Full Name
    N-acetylneuraminate pyruvate lyaseprovided by CGNC
    Primary source
    CGNC:3411
    See related
    Ensembl:ENSGALG00010011434
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See NPL in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (7432545..7442239)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (7444451..7465132)

    Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107053944 Neighboring gene small nucleolar RNA SNORD47 Neighboring gene small nucleolar RNA SNORD81 Neighboring gene heme binding protein 2 Neighboring gene microRNA 1618 Neighboring gene uncharacterized LOC121111370

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 4-hydroxy-tetrahydrodipicolinate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables N-acetylneuraminate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetylneuraminate lyase
    Names
    N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
    N-acetylneuraminic acid aldolase
    NALase
    sialate lyase
    sialate-pyruvate lyase
    sialic acid aldolase
    sialic acid lyase
    NP_001026731.2
    XP_025008665.2
    XP_040560658.1
    XP_040560659.1
    XP_040560660.1
    XP_040560661.1
    XP_040560663.1
    XP_040560664.1
    XP_046778913.1
    XP_046778914.1
    XP_046778915.1
    XP_046778916.1
    XP_046778917.1
    XP_046778918.1
    XP_046778919.1
    XP_046778920.1
    XP_046778921.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031560.3 → NP_001026731.2  N-acetylneuraminate lyase

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000237
      UniProtKB/Swiss-Prot
      Q5ZKD4
      UniProtKB/TrEMBL
      A0A8V0YD78
      Related
      ENSGALP00010015615.1, ENSGALT00010027361.1
      Conserved Domains (1) summary
      cl21457
      Location:7 → 297
      TIM; TIM-like beta/alpha barrel domains

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      7432545..7442239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040704724.2 → XP_040560658.1  N-acetylneuraminate lyase isoform X1

      UniProtKB/Swiss-Prot
      Q5ZKD4
      Conserved Domains (1) summary
      cl21457
      Location:23 → 298
      TIM; TIM-like beta/alpha barrel domains

    2. XM_040704726.2 → XP_040560660.1  N-acetylneuraminate lyase isoform X4

      UniProtKB/Swiss-Prot
      Q5ZKD4
      Conserved Domains (1) summary
      cl21457
      Location:23 → 278
      TIM; TIM-like beta/alpha barrel domains

    3. XM_040704725.2 → XP_040560659.1  N-acetylneuraminate lyase isoform X2

      UniProtKB/Swiss-Prot
      Q5ZKD4
      Conserved Domains (1) summary
      cl21457
      Location:19 → 294
      TIM; TIM-like beta/alpha barrel domains

    4. XM_040704730.2 → XP_040560664.1  N-acetylneuraminate lyase isoform X5

      Conserved Domains (1) summary
      cl21457
      Location:31 → 248
      TIM; TIM-like beta/alpha barrel domains

    5. XM_040704729.1 → XP_040560663.1  N-acetylneuraminate lyase isoform X5

      Conserved Domains (1) summary
      cl21457
      Location:31 → 248
      TIM; TIM-like beta/alpha barrel domains

    6. XM_040704727.1 → XP_040560661.1  N-acetylneuraminate lyase isoform X5

      Conserved Domains (1) summary
      cl21457
      Location:31 → 248
      TIM; TIM-like beta/alpha barrel domains

    7. XM_025152897.2 → XP_025008665.2  N-acetylneuraminate lyase isoform X3

      UniProtKB/Swiss-Prot
      Q5ZKD4
      Conserved Domains (1) summary
      cl21457
      Location:13 → 288
      TIM; TIM-like beta/alpha barrel domains

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      7444451..7465132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046922957.1 → XP_046778913.1  N-acetylneuraminate lyase isoform X1

      UniProtKB/Swiss-Prot
      Q5ZKD4

    2. XM_046922962.1 → XP_046778918.1  N-acetylneuraminate lyase isoform X4

      UniProtKB/Swiss-Prot
      Q5ZKD4

    3. XM_046922960.1 → XP_046778916.1  N-acetylneuraminate lyase isoform X2

      UniProtKB/Swiss-Prot
      Q5ZKD4

    4. XM_046922958.1 → XP_046778914.1  N-acetylneuraminate lyase isoform X6

      UniProtKB/Swiss-Prot
      Q5ZKD4
      UniProtKB/TrEMBL
      A0A8V0YD78

    5. XM_046922959.1 → XP_046778915.1  N-acetylneuraminate lyase isoform X6

      UniProtKB/Swiss-Prot
      Q5ZKD4
      UniProtKB/TrEMBL
      A0A8V0YD78

    6. XM_046922964.1 → XP_046778920.1  N-acetylneuraminate lyase isoform X5

    7. XM_046922965.1 → XP_046778921.1  N-acetylneuraminate lyase isoform X5

    8. XM_046922963.1 → XP_046778919.1  N-acetylneuraminate lyase isoform X5

    9. XM_046922961.1 → XP_046778917.1  N-acetylneuraminate lyase isoform X3

      UniProtKB/Swiss-Prot
      Q5ZKD4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ZKD4.1 GenPept UniProtKB/Swiss-Prot:Q5ZKD4

    Gene LinkOut

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