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    ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [ Gallus gallus (chicken) ]

    Gene ID: 424895, updated on 3-Dec-2024

    Summary

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    Symbol
    ACAP2provided by CGNC
    Full Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 2provided by CGNC
    Primary source
    CGNC:52279
    See related
    Ensembl:ENSGALG00010017500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    CENTB2; centaurin-beta-2
    Orthologs
    human mouse all
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    Genomic context

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    See ACAP2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (12378279..12434942)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (12181096..12237791)

    Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein D Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 2 Neighboring gene xyloside xylosyltransferase 1 Neighboring gene uncharacterized LOC107054105

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. Galan JA, et al. J Am Soc Mass Spectrom, 2011 Feb. PMID 21472591, Free PMC Article
    2. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
    Names
    centaurin, beta 2
    cnt-b2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006548.2 → NP_001006548.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001006548.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000240
      UniProtKB/Swiss-Prot
      Q5ZK62
      UniProtKB/TrEMBL
      A0A8V0Z2Y7
      Related
      ENSGALP00010024806.1, ENSGALT00010042316.1
      Conserved Domains (7) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd00204
      Location:610 → 728
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:269 → 365
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 361
      PH; PH domain
      pfam01412
      Location:399 → 517
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:612 → 706
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:610 → 638
      ANK; ANK repeat [structural motif]

    2. NM_001396171.1 → NP_001383100.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000240
      UniProtKB/TrEMBL
      A0A8V0Z2Y7
      Related
      ENSGALP00010024825.1, ENSGALT00010042335.1
      Conserved Domains (5) summary
      PTZ00322
      Location:651 → 735
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd13250
      Location:269 → 372
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:617 → 645
      ANK; ANK repeat [structural motif]
      cd08851
      Location:406 → 521
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      12378279..12434942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040705559.2 → XP_040561493.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q2U396
      Conserved Domains (6) summary
      PTZ00322
      Location:694 → 778
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:22 → 221
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:417 → 649
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:277 → 380
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:660 → 688
      ANK; ANK repeat [structural motif]
      cd08851
      Location:414 → 529
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

    2. XM_040705563.2 → XP_040561497.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8V0Z2Y7
      Conserved Domains (5) summary
      PTZ00322
      Location:659 → 743
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:22 → 221
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd13250
      Location:277 → 380
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:625 → 653
      ANK; ANK repeat [structural motif]
      cd08851
      Location:414 → 529
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

    3. XM_040705561.2 → XP_040561495.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q2U396
      Conserved Domains (6) summary
      PTZ00322
      Location:687 → 771
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:22 → 221
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:410 → 642
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:277 → 373
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:653 → 681
      ANK; ANK repeat [structural motif]
      cd08851
      Location:407 → 522
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

    4. XM_046898414.1 → XP_046754370.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A8V0Z2Y7

    5. XM_040705560.2 → XP_040561494.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q2U396
      Conserved Domains (6) summary
      PTZ00322
      Location:690 → 774
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:22 → 221
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:413 → 645
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:273 → 376
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:656 → 684
      ANK; ANK repeat [structural motif]
      cd08851
      Location:410 → 525
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

    6. XM_040705564.2 → XP_040561498.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8V0Z2Y7
      Conserved Domains (5) summary
      PTZ00322
      Location:655 → 739
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:22 → 221
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd13250
      Location:273 → 376
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:621 → 649
      ANK; ANK repeat [structural motif]
      cd08851
      Location:410 → 525
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

    7. XM_040705562.2 → XP_040561496.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A3Q2U396
      Conserved Domains (6) summary
      PTZ00322
      Location:683 → 767
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:22 → 221
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:406 → 638
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:273 → 369
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:649 → 677
      ANK; ANK repeat [structural motif]
      cd08851
      Location:403 → 518
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

    8. XM_040705566.2 → XP_040561500.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A8V0Z2Y7
      Related
      ENSGALP00010024814.1, ENSGALT00010042325.1
      Conserved Domains (5) summary
      PTZ00322
      Location:648 → 732
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:22 → 221
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd13250
      Location:273 → 369
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:614 → 642
      ANK; ANK repeat [structural motif]
      cd08851
      Location:403 → 518
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

    9. XM_015291391.4 → XP_015146877.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q2U396
      Conserved Domains (8) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:413 → 645
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd00204
      Location:656 → 774
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:273 → 376
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:271 → 372
      PH; PH domain
      pfam01412
      Location:410 → 528
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:658 → 752
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:656 → 684
      ANK; ANK repeat [structural motif]

    10. XM_015291392.4 → XP_015146878.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A3Q2U396
      Conserved Domains (8) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:409 → 641
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd00204
      Location:652 → 770
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:269 → 372
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 368
      PH; PH domain
      pfam01412
      Location:406 → 524
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:654 → 748
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:652 → 680
      ANK; ANK repeat [structural motif]

    11. XM_015291394.4 → XP_015146880.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A3Q2U396
      Related
      ENSGALP00010024810.1, ENSGALT00010042320.1
      Conserved Domains (8) summary
      cd07638
      Location:18 → 217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:402 → 634
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd00204
      Location:645 → 763
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:269 → 365
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 361
      PH; PH domain
      pfam01412
      Location:399 → 517
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:647 → 741
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:645 → 673
      ANK; ANK repeat [structural motif]

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      12181096..12237791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046923854.1 → XP_046779810.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q2U396

    2. XM_046923861.1 → XP_046779817.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8V0Z2Y7

    3. XM_046923857.1 → XP_046779813.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q2U396

    4. XM_046923863.1 → XP_046779819.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A8V0Z2Y7

    5. XM_046923856.1 → XP_046779812.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q2U396

    6. XM_046923862.1 → XP_046779818.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8V0Z2Y7

    7. XM_046923859.1 → XP_046779815.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A3Q2U396

    8. XM_046923864.1 → XP_046779820.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A8V0Z2Y7

    9. XM_046923855.1 → XP_046779811.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q2U396

    10. XM_046923858.1 → XP_046779814.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A3Q2U396

    11. XM_046923860.1 → XP_046779816.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A3Q2U396
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ZK62.1 GenPept UniProtKB/Swiss-Prot:Q5ZK62

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