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    AGO4 argonaute 4, RISC catalytic component [ Gallus gallus (chicken) ]

    Gene ID: 419629, updated on 17-Aug-2024

    Summary

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    Symbol
    AGO4provided by CGNC
    Full Name
    argonaute 4, RISC catalytic componentprovided by CGNC
    Primary source
    CGNC:66346
    See related
    Ensembl:ENSGALG00010015009
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    EIF2C4
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    Genomic context

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    See AGO4 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 23 NC_052554.1 (4573586..4586677, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 23 NC_052595.1 (4337097..4350188, complement)

    Chromosome 23 - NC_052554.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417362 Neighboring gene argonaute 3, RISC catalytic component Neighboring gene argonaute 1, RISC catalytic component Neighboring gene serine/arginine repetitive matrix protein 3-like Neighboring gene claspin Neighboring gene C1orf216 homolog Neighboring gene uncharacterized LOC101752244

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein argonaute-4
    Names
    argonaute RISC catalytic component 4
    eukaryotic translation initiation factor 2C, 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039276.2 → NP_001034365.1  protein argonaute-4 isoform 2

      See identical proteins and their annotated locations for NP_001034365.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000339
      UniProtKB/Swiss-Prot
      Q5ZMW0
      UniProtKB/TrEMBL
      A0A8V0YSC0
      Related
      ENSGALP00010020973.1, ENSGALT00010036112.1
      Conserved Domains (4) summary
      cd02846
      Location:150 → 270
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:317 → 752
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:99 → 149
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:4 → 88
      ArgoN; N-terminal domain of argonaute

    2. NM_001396480.1 → NP_001383409.1  protein argonaute-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000339
      UniProtKB/TrEMBL
      A0A1D5PZS8, A0A8V0YQP1
      Related
      ENSGALP00010020965.1, ENSGALT00010036101.1

    3. NM_001396481.1 → NP_001383410.1  protein argonaute-4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000339
      UniProtKB/Swiss-Prot
      Q5ZMW0
      UniProtKB/TrEMBL
      A0A8V0YSC0
      Conserved Domains (4) summary
      cd02846
      Location:150 → 270
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:317 → 752
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:99 → 149
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:4 → 88
      ArgoN; N-terminal domain of argonaute

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052554.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      4573586..4586677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052595.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      4337097..4350188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ZMW0.1 GenPept UniProtKB/Swiss-Prot:Q5ZMW0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.