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    TRAF2 TNF receptor associated factor 2 [ Gallus gallus (chicken) ]

    Gene ID: 417287, updated on 3-Dec-2024

    Summary

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    Symbol
    TRAF2provided by CGNC
    Full Name
    TNF receptor associated factor 2provided by CGNC
    Primary source
    CGNC:6850
    See related
    Ensembl:ENSGALG00010028458
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    TRAF2S
    Orthologs
    human mouse all
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    Genomic context

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    See TRAF2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 17 NC_052548.1 (1205517..1224558, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 17 NC_052589.1 (613437..632506, complement)

    Chromosome 17 - NC_052548.1Genomic Context describing neighboring genes Neighboring gene complement component 8, gamma polypeptide Neighboring gene F-box and WD repeat domain containing 5 Neighboring gene endothelial differentiation related factor 1 Neighboring gene MAM domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of plasma membrane signaling receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TNF receptor-associated factor 2
    XP_015135104.1
    XP_015135105.1
    XP_015135107.1
    XP_015135108.1
    XP_015135109.1
    XP_024997195.1
    XP_040541605.1
    XP_040541606.1
    XP_040541607.1
    XP_040541608.1
    XP_040541609.1
    XP_040541610.1
    XP_046757898.1
    XP_046785126.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      1205517..1224558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025141427.3 → XP_024997195.1  TNF receptor-associated factor 2 isoform X6

      UniProtKB/TrEMBL
      A0A8V1A8S1
      Related
      ENSGALP00010042358.1, ENSGALT00010068916.1
      Conserved Domains (4) summary
      pfam02176
      Location:141 → 198
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:49 → 90
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl02446
      Location:323 → 486
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:258 → 318
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    2. XM_015279623.4 → XP_015135109.1  TNF receptor-associated factor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8V1AKH9
      Related
      ENSGALP00010042359.1, ENSGALT00010068917.1
      Conserved Domains (4) summary
      pfam02176
      Location:195 → 252
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:49 → 90
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl02446
      Location:377 → 540
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:312 → 372
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    3. XM_015279621.3 → XP_015135107.1  TNF receptor-associated factor 2 isoform X3

      Conserved Domains (4) summary
      pfam02176
      Location:198 → 255
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:106 → 147
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl02446
      Location:380 → 543
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:315 → 375
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    4. XM_015279618.3 → XP_015135104.1  TNF receptor-associated factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V1AKH9
      Conserved Domains (4) summary
      pfam02176
      Location:252 → 309
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:106 → 147
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl02446
      Location:434 → 597
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:369 → 429
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    5. XM_015279622.4 → XP_015135108.1  TNF receptor-associated factor 2 isoform X4

      UniProtKB/TrEMBL
      A0A090JQG8
      Conserved Domains (4) summary
      pfam02176
      Location:124 → 181
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:32 → 73
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl02446
      Location:306 → 469
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:241 → 301
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    6. XM_015279619.4 → XP_015135105.1  TNF receptor-associated factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5P2Q9, A0A8V1AKH9, E1BTY1
      Conserved Domains (4) summary
      pfam02176
      Location:178 → 235
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:32 → 73
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl02446
      Location:360 → 523
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:295 → 355
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    7. XM_046901942.1 → XP_046757898.1  TNF receptor-associated factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5P2Q9, A0A8V1AKH9, E1BTY1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      613437..632506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040685676.2 → XP_040541610.1  TNF receptor-associated factor 2 isoform X6

      UniProtKB/TrEMBL
      A0A8V1A8S1
      Conserved Domains (4) summary
      pfam02176
      Location:141 → 198
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:49 → 90
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl02446
      Location:323 → 486
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:258 → 318
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    2. XM_040685675.2 → XP_040541609.1  TNF receptor-associated factor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8V1AKH9
      Conserved Domains (4) summary
      pfam02176
      Location:195 → 252
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:49 → 90
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl02446
      Location:377 → 540
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:312 → 372
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    3. XM_040685673.1 → XP_040541607.1  TNF receptor-associated factor 2 isoform X3

      Conserved Domains (4) summary
      pfam02176
      Location:198 → 255
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:106 → 147
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl02446
      Location:380 → 543
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:315 → 375
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    4. XM_040685671.1 → XP_040541605.1  TNF receptor-associated factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V1AKH9
      Conserved Domains (4) summary
      pfam02176
      Location:252 → 309
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:106 → 147
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl02446
      Location:434 → 597
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:369 → 429
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    5. XM_040685674.2 → XP_040541608.1  TNF receptor-associated factor 2 isoform X4

      UniProtKB/TrEMBL
      A0A090JQG8
      Conserved Domains (4) summary
      pfam02176
      Location:124 → 181
      zf-TRAF; TRAF-type zinc finger
      cd16639
      Location:32 → 73
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl02446
      Location:306 → 469
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:241 → 301
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    6. XM_040685672.2 → XP_040541606.1  TNF receptor-associated factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5P2Q9, A0A8V1AKH9, E1BTY1

    7. XM_046929170.1 → XP_046785126.1  TNF receptor-associated factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5P2Q9, A0A8V1AKH9, E1BTY1
    Nucleotide Protein
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