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    TRPM8 transient receptor potential cation channel subfamily M member 8 [ Gallus gallus (chicken) ]

    Gene ID: 424025, updated on 3-Dec-2024

    Summary

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    Symbol
    TRPM8provided by CGNC
    Full Name
    transient receptor potential cation channel subfamily M member 8provided by CGNC
    Primary source
    CGNC:52114
    See related
    Ensembl:ENSGALG00010012680
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See TRPM8 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (5594840..5670551)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (5535327..5611175)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene gastrulation brain homeobox 2 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 Neighboring gene secreted phosphoprotein 2 Neighboring gene uncharacterized LOC121111293

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two different avian cold-sensitive sensory neurons: Transient receptor potential melastatin 8 (TRPM8)-dependent and -independent activation mechanisms. Yamamoto A, et al. Neuropharmacology, 2016 Dec. PMID 27590914
    2. The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Chuang HH, et al. Neuron, 2004 Sep 16. PMID 15363396
    3. Camphor activates and sensitizes transient receptor potential melastatin 8 (TRPM8) to cooling and icilin. Selescu T, et al. Chem Senses, 2013 Sep. PMID 23828908
    4. The effects of neuronal cell differentiation on TRPM7, TRPM8 and TRPV1 channels in the model of Parkinson's disease. Öz A, et al. Neurol Res, 2022 Jan. PMID 34256685
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effects of neuronal cell differentiation on TRPM7, TRPM8 and TRPV1 channels in the model of Parkinson's disease.
      Title: The effects of neuronal cell differentiation on TRPM7, TRPM8 and TRPV1 channels in the model of Parkinson's disease.
    2. Results indicate that cTRPM8 acts as a cold-sensor similar to mammals. It is noteworthy that TRPM8-independent cold-sensitive neurons are abundant in chicken sensory neurons. Our results suggest that most of the cold-induced [Ca(2+)]i increases are mediated via Ca(2+) release from intracellular stores and that these mechanisms may be specific to avian species.
      Title: Two different avian cold-sensitive sensory neurons: Transient receptor potential melastatin 8 (TRPM8)-dependent and -independent activation mechanisms.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ligand-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transient receptor potential cation channel subfamily M member 8
    Names
    menthol receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007082.2 → NP_001007083.2  transient receptor potential cation channel subfamily M member 8

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000235
      UniProtKB/TrEMBL
      A0A8V0YA60, A0A8V0YGF8, Q5UKZ3
      Related
      ENSGALP00010017605.1, ENSGALT00010030351.1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      5594840..5670551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040703388.2 → XP_040559322.1  transient receptor potential cation channel subfamily M member 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YNB4
      Conserved Domains (1) summary
      TIGR00870
      Location:721 → 1044
      trp; transient-receptor-potential calcium channel protein

    2. XM_046943550.1 → XP_046799506.1  transient receptor potential cation channel subfamily M member 8 isoform X2

    3. XM_046943551.1 → XP_046799507.1  transient receptor potential cation channel subfamily M member 8 isoform X3

    4. XM_046943554.1 → XP_046799510.1  transient receptor potential cation channel subfamily M member 8 isoform X5

    5. XM_046943552.1 → XP_046799508.1  transient receptor potential cation channel subfamily M member 8 isoform X4

    6. XM_046943553.1 → XP_046799509.1  transient receptor potential cation channel subfamily M member 8 isoform X4

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      5535327..5611175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046921262.1 → XP_046777218.1  transient receptor potential cation channel subfamily M member 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YNB4

    2. XM_046921263.1 → XP_046777219.1  transient receptor potential cation channel subfamily M member 8 isoform X2

    3. XM_046921264.1 → XP_046777220.1  transient receptor potential cation channel subfamily M member 8 isoform X3

    4. XM_046921267.1 → XP_046777223.1  transient receptor potential cation channel subfamily M member 8 isoform X5

    5. XM_046921265.1 → XP_046777221.1  transient receptor potential cation channel subfamily M member 8 isoform X4

    6. XM_046921266.1 → XP_046777222.1  transient receptor potential cation channel subfamily M member 8 isoform X4

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials