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    NEDD4 NEDD4 E3 ubiquitin protein ligase [ Gallus gallus (chicken) ]

    Gene ID: 415406, updated on 3-Dec-2024

    Summary

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    Official Symbol
    NEDD4provided by CGNC
    Official Full Name
    NEDD4 E3 ubiquitin protein ligaseprovided by CGNC
    Primary source
    CGNC:3198
    See related
    Ensembl:ENSGALG00010022466
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See NEDD4 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (7788716..7838936)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (7661633..7711914)

    Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene testis expressed 9 Neighboring gene regulatory factor X7 Neighboring gene uncharacterized LOC107054174 Neighboring gene protogenin Neighboring gene pygopus family PHD finger 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sodium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of sodium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor internalization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase NEDD4
    Names
    neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
    XP_015147363.3
    XP_015147366.3
    XP_015147367.3
    XP_040535900.1
    XP_040535901.1
    XP_040535902.1
    XP_046755214.1
    XP_046781176.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      7788716..7838936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015291880.4 → XP_015147366.3  E3 ubiquitin-protein ligase NEDD4 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZVY4
      Related
      ENSGALP00010033018.1, ENSGALT00010054658.1
      Conserved Domains (4) summary
      cd04033
      Location:20 → 151
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:476 → 508
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:569 → 898
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:427 → 457
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    2. XM_015291881.4 → XP_015147367.3  E3 ubiquitin-protein ligase NEDD4 isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZVY4
      Conserved Domains (4) summary
      smart00456
      Location:357 → 389
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:450 → 779
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:308 → 338
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cl14603
      Location:1 → 32
      C2; C2 domain

    3. XM_046899258.1 → XP_046755214.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZQA3, A0A8V0ZVY4
      Related
      ENSGALP00010033011.1, ENSGALT00010054646.1

    4. XM_015291877.4 → XP_015147363.3  E3 ubiquitin-protein ligase NEDD4 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZVX3
      Related
      ENSGALP00010033008.1, ENSGALT00010054643.1
      Conserved Domains (4) summary
      smart00456
      Location:882 → 914
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:975 → 1304
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:833 → 863
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cl14603
      Location:504 → 557
      C2; C2 domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      7661633..7711914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040679967.2 → XP_040535901.1  E3 ubiquitin-protein ligase NEDD4 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZVY4
      Conserved Domains (4) summary
      cd04033
      Location:20 → 151
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:476 → 508
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:569 → 898
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:351 → 380
      WW; WW domain

    2. XM_040679968.2 → XP_040535902.1  E3 ubiquitin-protein ligase NEDD4 isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZVY4
      Conserved Domains (4) summary
      smart00456
      Location:357 → 389
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:450 → 779
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:308 → 338
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cl14603
      Location:1 → 32
      C2; C2 domain

    3. XM_046925220.1 → XP_046781176.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZVY4

    4. XM_040679966.2 → XP_040535900.1  E3 ubiquitin-protein ligase NEDD4 isoform X1

      Conserved Domains (4) summary
      smart00456
      Location:882 → 914
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:975 → 1304
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:833 → 863
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cl14603
      Location:504 → 557
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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