LRRN1 leucine rich repeat neuronal 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: LRRN1provided by CGNC
Full Name: leucine rich repeat neuronal 1provided by CGNC
Primary source: CGNC:56905
See related: Ensembl:ENSGALG00010020562
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: LRCH4
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	12	NC_052543.1 (18458125..18479460)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	12	NC_052584.1 (18496327..18517662)

Chromosome 12 - NC_052543.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lrrn1 may regulate the subcellular localisation of specific components of signalling or cell-cell recognition pathways in neuroepithelial cells.
Title: Analysis of Lrrn1 expression and its relationship to neuromeric boundaries during chick neural development.
Lrrn1's expression preconfigures the zona limitans thalami site before overt formation of this boundary structure
Title: Expression of Lrrn1 marks the prospective site of the zona limitans thalami in the early embryonic chicken diencephalon.
Lrrn1 is expressed in midbrain cells but not in anterior hindbrain cells. Lrrn1 is down-regulated in the anterior hindbrain by the organiser signalling molecule FGF8, thereby creating a differential affinity between these two compartments.
Title: Lrrn1 is required for formation of the midbrain-hindbrain boundary and organiser through regulation of affinity differences between midbrain and hindbrain cells in chick.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat neuronal protein 1

Names: leucine-rich repeats and calponin homology (CH) domain containing 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001097539.2 → NP_001091008.1 leucine-rich repeat neuronal protein 1 precursor

See identical proteins and their annotated locations for NP_001091008.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000252

UniProtKB/TrEMBL

A4ZZA2

Related

ENSGALP00010029333.1, ENSGALT00010049654.1

Conserved Domains (9) summary

smart00013
Location:32 → 75

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:371 → 418

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:89 → 180

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

pfam07679
Location:429 → 516

I-set; Immunoglobulin I-set domain

sd00031
Location:339 → 362

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:97 → 120

LRR_RI; leucine-rich repeat [structural motif]

pfam00041
Location:531 → 600

fn3; Fibronectin type III domain

pfam13855
Location:119 → 179

LRR_8; Leucine rich repeat

cl11960
Location:431 → 516

Ig; Immunoglobulin domain