IL10 interleukin 10 [Gallus gallus (chicken)] - Gene

Summary

Symbol: IL10provided by CGNC
Full Name: interleukin 10provided by CGNC
Primary source: CGNC:588
See related: Ensembl:ENSGALG00010027138
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: IL-10; interleukin-10
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 26

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	26	NC_052557.1 (2598173..2600538, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	26	NC_052598.1 (2568247..2570609, complement)

Chromosome 26 - NC_052557.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differences in spatial regulation of IL-10 and IFNgamma may indicate Eimeria species induce slightly different cytokine responses.
Title: Investigating the role of interleukin 10 on Eimeria intestinal pathogenesis in broiler chickens.
Data show that IL-10, IFN-gamma and TNF-alpha contents in the cecal tonsil were significantly decreased in the 30, 45 and 60 mg/kg groups, while IL-6 content in the cecal tonsil was only decreased in 60 mg/kg at 14 and 28 days of age.
Title: Changes of IgA+ cells and cytokines in the cecal tonsil of broilers fed on diets supplemented with vanadium.
Vitiligo in Smyth line chickens appears to be a Th1-polarized autoimmune disease, whereby IFN-gamma expression is strongly associated with parallel increases in IL-10 and IL-21, particularly during the early and active stages of vitiligo.
Title: IFN-γ, IL-21, and IL-10 co-expression in evolving autoimmune vitiligo lesions of Smyth line chickens.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004414.4 → NP_001004414.2 interleukin-10 precursor

See identical proteins and their annotated locations for NP_001004414.2

Status: VALIDATED

Source sequence(s)

JAENSK010000356

UniProtKB/Swiss-Prot

Q6A2H4, Q6A2H5

UniProtKB/TrEMBL

B6RCP7

Related

ENSGALP00010040060.1, ENSGALT00010065794.1

Conserved Domains (1) summary

cl02501
Location:33 → 169

IL10; Interleukin 10

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052557.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

2598173..2600538 complement

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GenBank, FASTA, Sequence Viewer (Graphics)