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    PHLDB1 pleckstrin homology like domain family B member 1 [ Homo sapiens (human) ]

    Gene ID: 23187, updated on 10-Dec-2024

    Summary

    Official Symbol
    PHLDB1provided by HGNC
    Official Full Name
    pleckstrin homology like domain family B member 1provided by HGNC
    Primary source
    HGNC:HGNC:23697
    See related
    Ensembl:ENSG00000019144 MIM:612834; AllianceGenome:HGNC:23697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LL5A; OI23; LL5alpha
    Summary
    Involved in regulation of embryonic development; regulation of epithelial to mesenchymal transition; and regulation of microtubule cytoskeleton organization. Located in several cellular components, including basal cortex; cytosol; and intercellular bridge. Implicated in osteogenesis imperfecta. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in fat (RPKM 23.2), brain (RPKM 15.4) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PHLDB1 in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (118606436..118658028)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118625712..118677249)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118477151..118528738)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 46 Neighboring gene uncharacterized LOC124902764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5595 Neighboring gene archain 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:118461541-118461751 Neighboring gene RNA, U6 small nuclear 1157, pseudogene Neighboring gene uncharacterized LOC124902765 Neighboring gene CRISPRi-validated cis-regulatory element chr11.5498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3949 Neighboring gene Sharpr-MPRA regulatory region 10010 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118479501-118480175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118480176-118480849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118486166-118486683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118486684-118487200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118488753-118489268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118501544-118502052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118502053-118502560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118505587-118506258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118514693-118515192 Neighboring gene microRNA 6716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118529141-118529690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118529691-118530240 Neighboring gene trehalase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118549589-118550250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118550251-118550910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118558272-118558787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118558788-118559302 Neighboring gene uncharacterized LOC105369519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5597 Neighboring gene trehalase pseudogene 1 Neighboring gene RNA, U6 small nuclear 376, pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Osteogenesis imperfecta, type 23
    MedGen: C5882757 OMIM: 620639 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
    EBI GWAS Catalog
    Chromosome 7p11.2 (EGFR) variation influences glioma risk.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog
    Genome-wide association study identifies five susceptibility loci for glioma.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ00141, FLJ90266, KIAA0638, MGC111531, DKFZp686H039, DKFZp686O24210

    General protein information

    Preferred Names
    pleckstrin homology-like domain family B member 1
    Names
    protein LL5-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144758.3NP_001138230.1  pleckstrin homology-like domain family B member 1 isoform a

      See identical proteins and their annotated locations for NP_001138230.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AB014538, AI917888, AK074918, AK125783, BX489377
      Consensus CDS
      CCDS8401.1
      UniProtKB/Swiss-Prot
      B0YJ63, B0YJ64, O75133, Q4KMF8, Q86UU1, Q8TEQ2
      UniProtKB/TrEMBL
      Q5W9G0
      Related
      ENSP00000469820.1, ENST00000600882.6
      Conserved Domains (6) summary
      cd14673
      Location:12551370
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:12581365
      PH; PH domain
      pfam00498
      Location:64124
      FHA; FHA domain
      pfam14988
      Location:728931
      DUF4515; Domain of unknown function (DUF4515)
      pfam15223
      Location:469552
      DUF4584; Domain of unknown function (DUF4584)
      cl19107
      Location:715812
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    2. NM_001144759.3NP_001138231.1  pleckstrin homology-like domain family B member 1 isoform b

      See identical proteins and their annotated locations for NP_001138231.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter, differs in the 5' UTR, and lacks two alternate in-frame exons in the coding region, compared to variant 1. The resulting isoform (b) lacks two internal segments, compared to isoform a.
      Source sequence(s)
      AB014538, AI917888, AK074918, AK125783, BX489377
      Consensus CDS
      CCDS44750.1
      UniProtKB/TrEMBL
      Q5W9G0
      Related
      ENSP00000348359.5, ENST00000356063.9
      Conserved Domains (7) summary
      COG1579
      Location:726930
      COG1579; Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only]
      cd14673
      Location:12081312
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:12111307
      PH; PH domain
      pfam00498
      Location:64124
      FHA; FHA domain
      pfam10473
      Location:676803
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:469552
      DUF4584; Domain of unknown function (DUF4584)
      cl19107
      Location:715812
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    3. NM_015157.4NP_055972.1  pleckstrin homology-like domain family B member 1 isoform a

      See identical proteins and their annotated locations for NP_055972.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AB094090, AI917888, AK125783, AP000941
      Consensus CDS
      CCDS8401.1
      UniProtKB/Swiss-Prot
      B0YJ63, B0YJ64, O75133, Q4KMF8, Q86UU1, Q8TEQ2
      UniProtKB/TrEMBL
      Q5W9G0
      Related
      ENSP00000354498.2, ENST00000361417.6
      Conserved Domains (6) summary
      cd14673
      Location:12551370
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:12581365
      PH; PH domain
      pfam00498
      Location:64124
      FHA; FHA domain
      pfam14988
      Location:728931
      DUF4515; Domain of unknown function (DUF4515)
      pfam15223
      Location:469552
      DUF4584; Domain of unknown function (DUF4584)
      cl19107
      Location:715812
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      118606436..118658028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542709.3XP_011541011.1  pleckstrin homology-like domain family B member 1 isoform X8

      See identical proteins and their annotated locations for XP_011541011.1

      Conserved Domains (7) summary
      cd14673
      Location:14181533
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:14211528
      PH; PH domain
      pfam00498
      Location:64124
      FHA; FHA domain
      pfam10473
      Location:676819
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:469552
      DUF4584; Domain of unknown function (DUF4584)
      cl02488
      Location:739940
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:715816
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    2. XM_047426640.1XP_047282596.1  pleckstrin homology-like domain family B member 1 isoform X32

      UniProtKB/TrEMBL
      Q5W9G0
    3. XM_047426637.1XP_047282593.1  pleckstrin homology-like domain family B member 1 isoform X30

      UniProtKB/TrEMBL
      Q5W9G0
    4. XM_047426638.1XP_047282594.1  pleckstrin homology-like domain family B member 1 isoform X31

    5. XM_047426639.1XP_047282595.1  pleckstrin homology-like domain family B member 1 isoform X32

      UniProtKB/TrEMBL
      Q5W9G0
    6. XM_047426641.1XP_047282597.1  pleckstrin homology-like domain family B member 1 isoform X33

      UniProtKB/TrEMBL
      Q5W9G0
    7. XM_011542708.4XP_011541010.1  pleckstrin homology-like domain family B member 1 isoform X8

      See identical proteins and their annotated locations for XP_011541010.1

      Conserved Domains (7) summary
      cd14673
      Location:14181533
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:14211528
      PH; PH domain
      pfam00498
      Location:64124
      FHA; FHA domain
      pfam10473
      Location:676819
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:469552
      DUF4584; Domain of unknown function (DUF4584)
      cl02488
      Location:739940
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:715816
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    8. XM_005271474.6XP_005271531.3  pleckstrin homology-like domain family B member 1 isoform X29

    9. XM_011542703.3XP_011541005.1  pleckstrin homology-like domain family B member 1 isoform X1

      Conserved Domains (6) summary
      cd14673
      Location:14641579
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:14671574
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722865
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl23750
      Location:785886
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    10. XM_011542704.3XP_011541006.1  pleckstrin homology-like domain family B member 1 isoform X3

      Conserved Domains (6) summary
      cd14673
      Location:14641568
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:14671563
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722865
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl23750
      Location:785886
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    11. XM_011542705.3XP_011541007.1  pleckstrin homology-like domain family B member 1 isoform X4

      Conserved Domains (6) summary
      cd14673
      Location:14491564
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:14521559
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722865
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl23750
      Location:785886
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    12. XM_011542706.3XP_011541008.1  pleckstrin homology-like domain family B member 1 isoform X5

      Conserved Domains (6) summary
      cd14673
      Location:14491553
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:14521548
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722865
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl23750
      Location:785886
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    13. XM_011542710.3XP_011541012.1  pleckstrin homology-like domain family B member 1 isoform X10

      Conserved Domains (4) summary
      PHA03307
      Location:198592
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:754986
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00060
      Location:85180
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14673
      Location:14071522
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
    14. XM_017017409.2XP_016872898.1  pleckstrin homology-like domain family B member 1 isoform X12

    15. XM_006718797.4XP_006718860.1  pleckstrin homology-like domain family B member 1 isoform X9

      Conserved Domains (7) summary
      cd14673
      Location:14161531
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:14191526
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722865
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl02488
      Location:785986
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:761862
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    16. XM_017017408.2XP_016872897.1  pleckstrin homology-like domain family B member 1 isoform X11

    17. XM_006718798.4XP_006718861.1  pleckstrin homology-like domain family B member 1 isoform X14

      Conserved Domains (7) summary
      cd14673
      Location:13591474
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:13621469
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722865
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl02488
      Location:785986
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:761862
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    18. XM_006718799.4XP_006718862.1  pleckstrin homology-like domain family B member 1 isoform X15

      Conserved Domains (7) summary
      cd14673
      Location:13441459
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:13471454
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722865
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl02488
      Location:785986
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:761862
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    19. XM_006718800.4XP_006718863.1  pleckstrin homology-like domain family B member 1 isoform X16

      Conserved Domains (7) summary
      cd14673
      Location:13441448
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:13471443
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722865
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl02488
      Location:785986
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:761862
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    20. XM_006718801.4XP_006718864.1  pleckstrin homology-like domain family B member 1 isoform X18

      Conserved Domains (7) summary
      cd14673
      Location:13121427
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:13151422
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722865
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl02488
      Location:785986
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:761862
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    21. XM_047426632.1XP_047282588.1  pleckstrin homology-like domain family B member 1 isoform X21

    22. XM_006718802.4XP_006718865.1  pleckstrin homology-like domain family B member 1 isoform X22

      Conserved Domains (7) summary
      cd14673
      Location:12971412
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:13001407
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722865
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl02488
      Location:785986
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:761862
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    23. XM_006718803.4XP_006718866.1  pleckstrin homology-like domain family B member 1 isoform X24

      Conserved Domains (7) summary
      cd14673
      Location:12971401
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:13001396
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722865
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl02488
      Location:785986
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:761862
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    24. XM_011542707.3XP_011541009.1  pleckstrin homology-like domain family B member 1 isoform X6

      Conserved Domains (8) summary
      cd14673
      Location:14211536
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:14241531
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722849
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cd16269
      Location:819832
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:758943
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:760847
      GBP_C; Guanylate-binding protein, C-terminal domain
    25. XM_017017410.2XP_016872899.1  pleckstrin homology-like domain family B member 1 isoform X13

    26. XM_005271468.4XP_005271525.1  pleckstrin homology-like domain family B member 1 isoform X17

      Conserved Domains (6) summary
      cd14673
      Location:13161431
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:13191426
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam14988
      Location:774977
      DUF4515; Domain of unknown function (DUF4515)
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl19107
      Location:761858
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    27. XM_005271469.4XP_005271526.1  pleckstrin homology-like domain family B member 1 isoform X19

      Conserved Domains (6) summary
      cd14673
      Location:13161420
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:13191415
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam14988
      Location:774977
      DUF4515; Domain of unknown function (DUF4515)
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl19107
      Location:761858
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    28. XM_005271470.4XP_005271527.1  pleckstrin homology-like domain family B member 1 isoform X20

      Conserved Domains (6) summary
      cd14673
      Location:13011416
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:13041411
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam14988
      Location:774977
      DUF4515; Domain of unknown function (DUF4515)
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl19107
      Location:761858
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    29. XM_005271471.4XP_005271528.1  pleckstrin homology-like domain family B member 1 isoform X23

      Conserved Domains (6) summary
      cd14673
      Location:13011405
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:13041400
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam14988
      Location:774977
      DUF4515; Domain of unknown function (DUF4515)
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl19107
      Location:761858
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    30. XM_005271472.4XP_005271529.1  pleckstrin homology-like domain family B member 1 isoform X26

      Conserved Domains (7) summary
      COG1579
      Location:772976
      COG1579; Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only]
      cd14673
      Location:12691384
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:12721379
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722849
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl19107
      Location:761858
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    31. XM_047426634.1XP_047282590.1  pleckstrin homology-like domain family B member 1 isoform X44

    32. XM_005271473.4XP_005271530.1  pleckstrin homology-like domain family B member 1 isoform X28

      Conserved Domains (7) summary
      COG1579
      Location:772976
      COG1579; Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only]
      cd14673
      Location:12541369
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:12571364
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:722849
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:515598
      DUF4584; Domain of unknown function (DUF4584)
      cl19107
      Location:761858
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    33. XM_005277680.4XP_005277737.1  pleckstrin homology-like domain family B member 1 isoform X2

      Conserved Domains (6) summary
      cd14673
      Location:14631578
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:14661573
      PH; PH domain
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam10473
      Location:721864
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam15223
      Location:514597
      DUF4584; Domain of unknown function (DUF4584)
      cl23750
      Location:784885
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    34. XM_047426633.1XP_047282589.1  pleckstrin homology-like domain family B member 1 isoform X25

    35. XM_017017407.2XP_016872896.1  pleckstrin homology-like domain family B member 1 isoform X7

    36. XM_047426635.1XP_047282591.1  pleckstrin homology-like domain family B member 1 isoform X27

    37. XM_047426636.1XP_047282592.1  pleckstrin homology-like domain family B member 1 isoform X45

    38. XM_047426648.1XP_047282604.1  pleckstrin homology-like domain family B member 1 isoform X40

    39. XM_005271475.4XP_005271532.1  pleckstrin homology-like domain family B member 1 isoform X41

      Conserved Domains (2) summary
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam13863
      Location:760840
      DUF4200; Domain of unknown function (DUF4200)
    40. XM_017017411.2XP_016872900.1  pleckstrin homology-like domain family B member 1 isoform X41

      Conserved Domains (2) summary
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam13863
      Location:760840
      DUF4200; Domain of unknown function (DUF4200)
    41. XM_011542714.3XP_011541016.1  pleckstrin homology-like domain family B member 1 isoform X42

      Conserved Domains (2) summary
      pfam00498
      Location:110170
      FHA; FHA domain
      pfam13863
      Location:760839
      DUF4200; Domain of unknown function (DUF4200)
    42. XM_047426645.1XP_047282601.1  pleckstrin homology-like domain family B member 1 isoform X37

      UniProtKB/TrEMBL
      Q5W9G0
    43. XM_047426642.1XP_047282598.1  pleckstrin homology-like domain family B member 1 isoform X34

      UniProtKB/TrEMBL
      Q5W9G0
    44. XM_047426647.1XP_047282603.1  pleckstrin homology-like domain family B member 1 isoform X39

      UniProtKB/TrEMBL
      Q5W9G0
    45. XM_047426644.1XP_047282600.1  pleckstrin homology-like domain family B member 1 isoform X36

      UniProtKB/TrEMBL
      Q5W9G0
      Related
      ENST00000532517.5
    46. XM_047426646.1XP_047282602.1  pleckstrin homology-like domain family B member 1 isoform X38

      UniProtKB/TrEMBL
      Q5W9G0
    47. XM_047426643.1XP_047282599.1  pleckstrin homology-like domain family B member 1 isoform X35

      UniProtKB/TrEMBL
      Q5W9G0
    48. XM_011542715.4XP_011541017.1  pleckstrin homology-like domain family B member 1 isoform X43

      UniProtKB/TrEMBL
      Q96D60
      Related
      ENST00000614369.4
      Conserved Domains (3) summary
      cd14673
      Location:610714
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:613709
      PH; PH domain
      cl19107
      Location:117214
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RNA

    1. XR_947813.3 RNA Sequence

    2. XR_007062463.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      118625712..118677249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368149.1XP_054224124.1  pleckstrin homology-like domain family B member 1 isoform X8

    2. XM_054368173.1XP_054224148.1  pleckstrin homology-like domain family B member 1 isoform X30

      UniProtKB/TrEMBL
      Q5W9G0
    3. XM_054368174.1XP_054224149.1  pleckstrin homology-like domain family B member 1 isoform X31

    4. XM_054368175.1XP_054224150.1  pleckstrin homology-like domain family B member 1 isoform X32

      UniProtKB/TrEMBL
      Q5W9G0
    5. XM_054368177.1XP_054224152.1  pleckstrin homology-like domain family B member 1 isoform X33

      UniProtKB/TrEMBL
      Q5W9G0
    6. XM_054368148.1XP_054224123.1  pleckstrin homology-like domain family B member 1 isoform X8

    7. XM_054368176.1XP_054224151.1  pleckstrin homology-like domain family B member 1 isoform X32

      UniProtKB/TrEMBL
      Q5W9G0
    8. XM_054368171.1XP_054224146.1  pleckstrin homology-like domain family B member 1 isoform X29

    9. XM_054368141.1XP_054224116.1  pleckstrin homology-like domain family B member 1 isoform X1

    10. XM_054368143.1XP_054224118.1  pleckstrin homology-like domain family B member 1 isoform X3

    11. XM_054368144.1XP_054224119.1  pleckstrin homology-like domain family B member 1 isoform X4

    12. XM_054368145.1XP_054224120.1  pleckstrin homology-like domain family B member 1 isoform X5

    13. XM_054368151.1XP_054224126.1  pleckstrin homology-like domain family B member 1 isoform X10

    14. XM_054368153.1XP_054224128.1  pleckstrin homology-like domain family B member 1 isoform X12

    15. XM_054368150.1XP_054224125.1  pleckstrin homology-like domain family B member 1 isoform X9

    16. XM_054368152.1XP_054224127.1  pleckstrin homology-like domain family B member 1 isoform X11

    17. XM_054368155.1XP_054224130.1  pleckstrin homology-like domain family B member 1 isoform X14

    18. XM_054368156.1XP_054224131.1  pleckstrin homology-like domain family B member 1 isoform X15

    19. XM_054368157.1XP_054224132.1  pleckstrin homology-like domain family B member 1 isoform X16

    20. XM_054368159.1XP_054224134.1  pleckstrin homology-like domain family B member 1 isoform X18

    21. XM_054368162.1XP_054224137.1  pleckstrin homology-like domain family B member 1 isoform X21

    22. XM_054368163.1XP_054224138.1  pleckstrin homology-like domain family B member 1 isoform X22

    23. XM_054368165.1XP_054224140.1  pleckstrin homology-like domain family B member 1 isoform X24

    24. XM_054368146.1XP_054224121.1  pleckstrin homology-like domain family B member 1 isoform X6

    25. XM_054368154.1XP_054224129.1  pleckstrin homology-like domain family B member 1 isoform X13

    26. XM_054368158.1XP_054224133.1  pleckstrin homology-like domain family B member 1 isoform X17

    27. XM_054368160.1XP_054224135.1  pleckstrin homology-like domain family B member 1 isoform X19

    28. XM_054368161.1XP_054224136.1  pleckstrin homology-like domain family B member 1 isoform X20

    29. XM_054368164.1XP_054224139.1  pleckstrin homology-like domain family B member 1 isoform X23

    30. XM_054368167.1XP_054224142.1  pleckstrin homology-like domain family B member 1 isoform X26

    31. XM_054368170.1XP_054224145.1  pleckstrin homology-like domain family B member 1 isoform X28

    32. XM_054368142.1XP_054224117.1  pleckstrin homology-like domain family B member 1 isoform X2

    33. XM_054368166.1XP_054224141.1  pleckstrin homology-like domain family B member 1 isoform X25

    34. XM_054368147.1XP_054224122.1  pleckstrin homology-like domain family B member 1 isoform X7

    35. XM_054368169.1XP_054224144.1  pleckstrin homology-like domain family B member 1 isoform X27

    36. XM_054368184.1XP_054224159.1  pleckstrin homology-like domain family B member 1 isoform X40

    37. XM_054368186.1XP_054224161.1  pleckstrin homology-like domain family B member 1 isoform X41

    38. XM_054368185.1XP_054224160.1  pleckstrin homology-like domain family B member 1 isoform X41

    39. XM_054368187.1XP_054224162.1  pleckstrin homology-like domain family B member 1 isoform X42

    40. XM_054368168.1XP_054224143.1  pleckstrin homology-like domain family B member 1 isoform X46

    41. XM_054368172.1XP_054224147.1  pleckstrin homology-like domain family B member 1 isoform X47

    42. XM_054368181.1XP_054224156.1  pleckstrin homology-like domain family B member 1 isoform X37

      UniProtKB/TrEMBL
      Q5W9G0
    43. XM_054368178.1XP_054224153.1  pleckstrin homology-like domain family B member 1 isoform X34

      UniProtKB/TrEMBL
      Q5W9G0
    44. XM_054368183.1XP_054224158.1  pleckstrin homology-like domain family B member 1 isoform X39

      UniProtKB/TrEMBL
      Q5W9G0
    45. XM_054368180.1XP_054224155.1  pleckstrin homology-like domain family B member 1 isoform X36

      UniProtKB/TrEMBL
      Q5W9G0
    46. XM_054368182.1XP_054224157.1  pleckstrin homology-like domain family B member 1 isoform X38

      UniProtKB/TrEMBL
      Q5W9G0
    47. XM_054368179.1XP_054224154.1  pleckstrin homology-like domain family B member 1 isoform X35

      UniProtKB/TrEMBL
      Q5W9G0
    48. XM_054368188.1XP_054224163.1  pleckstrin homology-like domain family B member 1 isoform X43

      UniProtKB/TrEMBL
      Q96D60

    RNA

    1. XR_008488368.1 RNA Sequence

    2. XR_008488367.1 RNA Sequence