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    JADE1 jade family PHD finger 1 [ Homo sapiens (human) ]

    Gene ID: 79960, updated on 10-Dec-2024

    Summary

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    Official Symbol
    JADE1provided by HGNC
    Official Full Name
    jade family PHD finger 1provided by HGNC
    Primary source
    HGNC:HGNC:30027
    See related
    Ensembl:ENSG00000077684 MIM:610514; AllianceGenome:HGNC:30027
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PHF17
    Summary
    Enables transcription coactivator activity. Contributes to histone acetyltransferase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; regulation of cell growth; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in several cellular components, including cytosol; microtubule organizing center; and nuclear speck. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 13.1), ovary (RPKM 12.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See JADE1 in Genome Data Viewer
    Location:
    4q28.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (128809700..128875224)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (132113886..132179423)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (129730855..129796379)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 3140 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129535873-129536374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129536375-129536874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:129560764-129561264 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129565349-129565848 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:129569028-129569766 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129573717-129574216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21893 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:129603876-129604400 Neighboring gene Sharpr-MPRA regulatory region 780 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129605286-129606025 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:129606954-129608153 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129613233-129613734 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74071 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74072 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129654815-129655316 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129655317-129655816 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr4:129697052-129697573 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129723780-129724699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129734111-129734692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:129734693-129735274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21898 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:129752609-129753288 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:129753289-129753968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129756920-129757462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21901 Neighboring gene sodium channel and clathrin linker 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21902 Neighboring gene chromosome 4 open reading frame 33 Neighboring gene CDRT15 pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Jade-1, a candidate renal tumor suppressor that promotes apoptosis. Zhou MI, et al. Proc Natl Acad Sci U S A, 2005 Aug 2. PMID 16046545, Free PMC Article
    2. Structure, function and regulation of jade family PHD finger 1 (JADE1). Panchenko MV. Gene, 2016 Sep 1. PMID 27155521, Free PMC Article
    3. The novel function of JADE1S in cytokinesis of epithelial cells. Siriwardana NS, et al. Cell Cycle, 2015. PMID 26151225, Free PMC Article
    4. MicroRNA-155-5p Targets JADE-1, Promoting Proliferation, Migration, and Invasion in Clear Cell Renal Cell Carcinoma Cells. Kalantzakos T, et al. Int J Mol Sci, 2023 Apr 25. PMID 37175531, Free PMC Article
    5. Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent. Zhou MI, et al. Cancer Res, 2004 Feb 15. PMID 14973063

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-155-5p Targets JADE-1, Promoting Proliferation, Migration, and Invasion in Clear Cell Renal Cell Carcinoma Cells.
      Title: MicroRNA-155-5p Targets JADE-1, Promoting Proliferation, Migration, and Invasion in Clear Cell Renal Cell Carcinoma Cells.
    2. Genome-wide association study and functional validation implicates JADE1 in tauopathy.
      Title: Genome-wide association study and functional validation implicates JADE1 in tauopathy.
    3. results indicate that the N-terminal region of JADE1 functions as a platform that brings together the catalytic HBO1 subunit with its cognate H3-H4 substrate for histone acetylation
      Title: The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate.
    4. identification of SNPs within the IQCJ, NXPH1, PHF17 and MYB genes partly explaining the large interindividual variability observed in plasma triglyceride levels in response to an n-3 fatty acid supplementation
      Title: Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation.
    5. A genome-wide association study (GWAS) identified loci associated with the plasma triglyceride (TG) response to omega-3 fatty acid (FA) supplementation in IQCJ, NXPH1, PHF17 and MYB.
      Title: Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans.
    6. JADE1 expression has a role in colon cancers, renal carcinomas, and in acute kidney injuries and regeneration. (Review)
      Title: Structure, function and regulation of jade family PHD finger 1 (JADE1).
    7. Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.
      Title: Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.
    8. JADE1S protein localized to centrosomes in interphase and mitotic cells, and to the midbody during cytokinesis.
      Title: The novel function of JADE1S in cytokinesis of epithelial cells.
    9. Casein kinase 1 alpha specifically phosphorylates Jade-1 at an unprimed SLS phosphorylation site.
      Title: Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity.
    10. Increase in the number of cells with cytoplasmic JADE1S correlated with activation of tubular cell proliferation and inversely correlated with the number of cells with nuclear JADE1S, supporting role of HBO1-JADE1 shuttling during organ regeneration.
      Title: Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22479, KIAA1807

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to histone H3K14 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H4K12 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT contributes_to histone H4K16 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H4K5 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H4K8 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein Jade-1
    Names
    PHD finger protein 17
    PHD protein Jade-1
    gene for apoptosis and differentiation in epithelia
    jade family PHD finger protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287437.2 → NP_001274366.1  protein Jade-1 isoform 3

      See identical proteins and their annotated locations for NP_001274366.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC093783, AK027620, AK127326, BI463062
      Consensus CDS
      CCDS75191.1
      UniProtKB/TrEMBL
      B4E2E2
      Related
      ENSP00000388015.2, ENST00000452328.6
      Conserved Domains (2) summary
      cd15671
      Location:246 → 356
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
      cl26518
      Location:88 → 517
      EPL1; Enhancer of polycomb-like

    2. NM_001287439.2 → NP_001274368.1  protein Jade-1 isoform 1

      See identical proteins and their annotated locations for NP_001274368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 7, and 8 encode the same isoform (1).
      Source sequence(s)
      AC093783, AK304235, BN000287, DC308588
      Consensus CDS
      CCDS34062.1
      UniProtKB/Swiss-Prot
      D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
      UniProtKB/TrEMBL
      B4E2E2
      Related
      ENSP00000425730.1, ENST00000512960.5
      Conserved Domains (2) summary
      COG5141
      Location:99 → 529
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15671
      Location:258 → 368
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

    3. NM_001287440.2 → NP_001274369.1  protein Jade-1 isoform 1

      See identical proteins and their annotated locations for NP_001274369.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 7, and 8 encode the same isoform (1).
      Source sequence(s)
      AC093783, BN000287, DA478923
      Consensus CDS
      CCDS34062.1
      UniProtKB/Swiss-Prot
      D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
      UniProtKB/TrEMBL
      B4E2E2
      Conserved Domains (2) summary
      COG5141
      Location:99 → 529
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15671
      Location:258 → 368
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

    4. NM_001287441.2 → NP_001274370.1  protein Jade-1 isoform 2

      See identical proteins and their annotated locations for NP_001274370.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks two exons, and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.
      Source sequence(s)
      AF520952, AK074986, BC032376, BX107708, DA714593
      Consensus CDS
      CCDS47134.1
      UniProtKB/Swiss-Prot
      Q6IE81
      Related
      ENSP00000404211.2, ENST00000413543.6
      Conserved Domains (2) summary
      cd15704
      Location:255 → 372
      ePHD_JADE1; Extended PHD finger found in protein Jade-1 and similar proteins
      cl26518
      Location:99 → 503
      EPL1; Enhancer of polycomb-like

    5. NM_001287442.1 → NP_001274371.1  protein Jade-1 isoform 1

      See identical proteins and their annotated locations for NP_001274371.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 7, and 8 encode the same isoform (1).
      Source sequence(s)
      AC093783, BN000287, DA714593, DB293142
      Consensus CDS
      CCDS34062.1
      UniProtKB/Swiss-Prot
      D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
      UniProtKB/TrEMBL
      B4E2E2
      Related
      ENSP00000483219.1, ENST00000610919.4
      Conserved Domains (2) summary
      COG5141
      Location:99 → 529
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15671
      Location:258 → 368
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

    6. NM_001287443.1 → NP_001274372.1  protein Jade-1 isoform 1

      See identical proteins and their annotated locations for NP_001274372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 7, and 8 encode the same isoform (1).
      Source sequence(s)
      AC093783, AC108024, BN000287, DB085413
      Consensus CDS
      CCDS34062.1
      UniProtKB/Swiss-Prot
      D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
      UniProtKB/TrEMBL
      B4E2E2
      Related
      ENSP00000482212.1, ENST00000611140.4
      Conserved Domains (2) summary
      COG5141
      Location:99 → 529
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15671
      Location:258 → 368
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

    7. NM_024900.5 → NP_079176.2  protein Jade-1 isoform 2

      See identical proteins and their annotated locations for NP_079176.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.
      Source sequence(s)
      AF520952, AK027620, AK074986, BI463062, BX107708
      Consensus CDS
      CCDS47134.1
      UniProtKB/Swiss-Prot
      Q6IE81
      Related
      ENSP00000423737.1, ENST00000511647.5
      Conserved Domains (2) summary
      cd15704
      Location:255 → 372
      ePHD_JADE1; Extended PHD finger found in protein Jade-1 and similar proteins
      cl26518
      Location:99 → 503
      EPL1; Enhancer of polycomb-like

    8. NM_199320.4 → NP_955352.1  protein Jade-1 isoform 1

      See identical proteins and their annotated locations for NP_955352.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4, 5, 7, and 8 encode the same isoform.
      Source sequence(s)
      AC093783, AK027620, BI463062, BN000287
      Consensus CDS
      CCDS34062.1
      UniProtKB/Swiss-Prot
      D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
      UniProtKB/TrEMBL
      B4E2E2
      Related
      ENSP00000226319.6, ENST00000226319.11
      Conserved Domains (2) summary
      COG5141
      Location:99 → 529
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15671
      Location:258 → 368
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      128809700..128875224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008626.3 → XP_016864115.1  protein Jade-1 isoform X4

      Conserved Domains (2) summary
      cd15704
      Location:255 → 372
      ePHD_JADE1; Extended PHD finger found in protein Jade-1 and similar proteins
      cl26518
      Location:99 → 502
      EPL1; Enhancer of polycomb-like

    2. XM_024454219.2 → XP_024309987.1  protein Jade-1 isoform X3

      UniProtKB/TrEMBL
      B4E2E2
      Conserved Domains (2) summary
      cd15671
      Location:271 → 381
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
      cl26518
      Location:112 → 542
      EPL1; Enhancer of polycomb-like

    3. XM_017008627.2 → XP_016864116.1  protein Jade-1 isoform X4

      Conserved Domains (2) summary
      cd15704
      Location:255 → 372
      ePHD_JADE1; Extended PHD finger found in protein Jade-1 and similar proteins
      cl26518
      Location:99 → 502
      EPL1; Enhancer of polycomb-like

    4. XM_024454217.2 → XP_024309985.1  protein Jade-1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
      UniProtKB/TrEMBL
      B4E2E2
      Conserved Domains (2) summary
      COG5141
      Location:99 → 529
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15671
      Location:258 → 368
      ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

    5. XM_024454221.2 → XP_024309989.1  protein Jade-1 isoform X4

      Conserved Domains (2) summary
      cd15704
      Location:255 → 372
      ePHD_JADE1; Extended PHD finger found in protein Jade-1 and similar proteins
      cl26518
      Location:99 → 502
      EPL1; Enhancer of polycomb-like

    6. XM_024454218.2 → XP_024309986.1  protein Jade-1 isoform X2

      UniProtKB/TrEMBL
      B4E2E2
      Conserved Domains (2) summary
      cd15704
      Location:270 → 387
      ePHD_JADE1; Extended PHD finger found in protein Jade-1 and similar proteins
      cl26518
      Location:114 → 544
      EPL1; Enhancer of polycomb-like

    7. XM_047416183.1 → XP_047272139.1  protein Jade-1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
      UniProtKB/TrEMBL
      B4E2E2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      132113886..132179423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350862.1 → XP_054206837.1  protein Jade-1 isoform X4

    2. XM_054350859.1 → XP_054206834.1  protein Jade-1 isoform X3

      UniProtKB/TrEMBL
      B4E2E2

    3. XM_054350863.1 → XP_054206838.1  protein Jade-1 isoform X4

    4. XM_054350857.1 → XP_054206832.1  protein Jade-1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
      UniProtKB/TrEMBL
      B4E2E2

    5. XM_054350861.1 → XP_054206836.1  protein Jade-1 isoform X4

    6. XM_054350858.1 → XP_054206833.1  protein Jade-1 isoform X2

      UniProtKB/TrEMBL
      B4E2E2

    7. XM_054350860.1 → XP_054206835.1  protein Jade-1 isoform X1

      UniProtKB/Swiss-Prot
      D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
      UniProtKB/TrEMBL
      B4E2E2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IE81.1 GenPept UniProtKB/Swiss-Prot:Q6IE81

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